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UnknownIn Vivo HSC Gene Therapy Using a Bi-modular HDAd5/35++ Vector Cures Sickle Cell Disease in a Mouse Model.
We have recently reported that, after in vivo hematopoietic stem cell/progenitor (HSPC) transduction with HDAd5/35++ vectors, SB100x transposase-mediated γ-globin gene addition achieved 10%-15% γ-globin of adult mouse globin, resulting in significant but incomplete phenotypic correction in a thalass...
S-EPMC7854285 | biostudies-literature
UnknownCognitive Impairment in Parkinson's Disease: An Updated Overview Focusing on Emerging Pharmaceutical Treatment Approaches.
Cognitive impairment in patients with Parkinson's disease (PD) is one of the commonest and most disabling non-motor manifestations during the course of the disease. The clinical spectrum of PD-related cognitive impairment includes subjective cognitive decline (SCD), mild cognitive impairment (MCI) a...
S-EPMC10608778 | biostudies-literature
UnknownSmall airways dysfunction in patients with systemic sclerosis and interstitial lung disease.

Background

A number of studies report small airways involvement in patients with systemic sclerosis (SSc). Furthermore, small airways dysfunction is increasingly recognized in patients with interstitial lung disease (ILD) of idiopathic or autoimmune etiology. The objectives of this study wer...
S-EPMC9702077 | biostudies-literature
UnknownPixlMap: A generalisable pixel classifier for cellular phenotyping in multiplex immunofluorescence images.
Multiplexed methods for the detection of protein expression generate extremely data-rich images of intact tissue sections. These images are invaluable for the quantification and analysis of complex biology and biomarker development. However, their interpretation presents a considerable analytical ch...
S-EPMC12674528 | biostudies-literature
UnknownPulmonary function testing in patients with liver cirrhosis (Review).
Liver cirrhosis is a common long-term outcome of chronic hepatic inflammation. Patients with liver cirrhosis may also have pulmonary complications. There are several reasons for pulmonary dysfunction in liver cirrhosis, including intrinsic cardiopulmonary dysfunction unrelated to liver disease and s...
S-EPMC10391595 | biostudies-literature
UnknownCircular dichroism of carotenoids in bacterial light-harvesting complexes: experiments and modeling.
In this work we investigate the origin and characteristics of the circular dichroism (CD) spectrum of rhodopin glucoside and lycopene in the light-harvesting 2 complex of Rhodopseudomonas acidophila and Rhodospirillum molischianum, respectively. We successfully model their absorption and CD spectra ...
S-EPMC1304774 | biostudies-literature
UnknownMethane Catalytic Combustion under Lean Conditions over Pristine and Ir-Loaded La1-xSrxMnO3 Perovskites: Efficiency, Hysteresis, and Time-on-Stream and Thermal Aging Stabilities.
The increasing use of natural gas as an efficient, reliable, affordable, and cleaner energy source, compared with other fossil fuels, has brought the catalytic CH4 complete oxidation reaction into the spotlight as a simple and economic way to control the amount of unconverted methane esca...
S-EPMC10420673 | biostudies-literature
UnknownSurveillance of Acute Flaccid Paralysis (AFP) in Greece: 2008-2024.
As part of the WHO's Global Polio Eradication Initiative, acute flaccid paralysis (AFP) surveillance in children under 15 years old is crucial for monitoring the emergence of polioviruses and tracking Non-Polio Enteroviruses (NPEVs). This study outlines the past 17 years of AFP surveillance in Greec...
S-EPMC12567247 | biostudies-literature
UnknownIn vivo HSPC gene therapy with base editors allows for efficient reactivation of fetal γ-globin in β-YAC mice.
Base editors are capable of installing precise genomic alterations without creating double-strand DNA breaks. In this study, we targeted critical motifs regulating γ-globin reactivation with base editors delivered via HDAd5/35++ vectors. Through optimized design, we successfully produced a panel of ...
S-EPMC7903237 | biostudies-literature
UnknownHDAd6/35++ - A new helper-dependent adenovirus vector platform for in vivo transduction of hematopoietic stem cells.
In previous studies, we achieved safe and efficient in vivo hematopoietic stem cell (HSC) transduction in mobilized mice and macaques with intravenously injected helper-dependent adenovirus HDAd5/35++ vectors. These vectors are derivatives of serotype Ad5-containing CD46-affinity enhanced Ad3...
S-EPMC10111954 | biostudies-literature
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