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MetabolomicsAtlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Folates participate in the one-carbon metabolism (OCM) cycle, supporting many biochemical pathways. Existing methods to profile folate are limited in the diversity of vitamers they measure and the samples they profile. We present a metabolomics workflow for stable extraction, separation, and meas...

2026-02-10 | MTBLS13484 | MetaboLights
TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (mRNA analysis)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59252 | biostudies-arrayexpress
MetabolomicsHarnessing a Germ-Free Mouse Gut Bioreactor for Directed Evolution of Probiotics to Combat NAFLD

The data uploaded in this study were obtained from an interventional experiment in which non-alcoholic fatty liver disease (NAFLD) model mice were treated with either the original or adapted bacterial strains, followed by fecal sample collection and targeted bile acid metabolomic analysis.

2026-01-20 | MTBLS13718 | MetaboLights
TranscriptomicsGene-expression profile of human embryonic germ cells
Gene-expression profile of human embryonic germ cells (EGCs), primordial germ cells (PGCs), embryonal carcinoma cells (ECCs), pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs)
ORGANISM(S): Homo sapiens 
2018-06-28 | E-MTAB-6851 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of mouse germ cells
Spermatogenesis is a recurring differentiation process that results in the production of male gametes within the testes. During this process, spermatogonial stem cells differentiate to form spermatocytes, which undergo two rounds of meiotic division to form haploid spermatids. Throughout spermiogene...
ORGANISM(S): Mus musculus 
2019-01-25 | E-MTAB-6946 | biostudies-arrayexpress
GenomicsSeminoma and embryonal carcinoma footprints identified by analysis of integrated genome-wide epigenetic and expression profiles of germ cell cancer cell lines (ChIP-seq data).
Background: Germ Cell Cancers (GCC), originating from Primordial Germ Cells /gonocytes, are the most common cancer in young men, subdivided in seminoma (SE) and non-seminoma (NS, stem cell component: embryonal carcinoma (EC)). Somatic mutations are rarely found in GCC. It has been proposed that disr...
ORGANISM(S): Homo sapiens 
2014-06-01 | E-GEOD-56450 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human pediatric malignant germ cell tumors
To compare the transcriptome profiles of the two principal histological variants of malignant germ cell tumor that occur in childhood Experiment Overall Design: Here, we analyzed the global gene expression profiles of 27 pediatric MGCTs from the two principal histologies (18 yolk sac tumors [YSTs] a...
ORGANISM(S): Homo sapiens 
2008-06-18 | E-GEOD-10615 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult male germ cell tumours
Expression profiling of a panel of 101 adult male germ cell tumors and 5 normal testis specimens was performed on Affymetrix U133A and U133B microarrays. This data has been used to:; 1) generate a gene classifier that predicts histology (see PMID 15870693). 2) identify candidate target genes on 12p,...
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-3218 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of embryonic stem cell differentiation into the three germ layers
This SuperSeries is composed of the following subset Series: GSE32080: DNA methylation profiling of embryonic stem cell differentiation into the three germ layers [MeDIP analysis] GSE32081: DNA methylation profiling of embryonic stem cell differentiation into the three germ layers [Expression analys...
ORGANISM(S): Mus musculus 
2012-02-15 | E-GEOD-32082 | biostudies-arrayexpress
ProteomicsProteomic profiling of cisplatin-resistant and cisplatin-sensitive germ cell tumor cell lines using quantitative mass spectrometry
Testicular germ cell tumors (GCTs) are the most common malignant solid neoplasms in men between the age of 15 and 40 with an increasing incidence seen over the last four decades. Histologically, type II GCT are divided into seminomas (SEM) and non-seminomatous GCT (NSGCT) according to the WHO. NSGCT...
ORGANISM(S): Homo sapiens (Human) 
2022-04-01 | PXD030251 | Pride
Proteomic analysis Cisplatin resistance Mass spectrometry Silac Germ cell tumor 
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