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MetabolomicsAtlas of one-carbon metabolism in conventional and germ-free mice reveals folate as a key determinant of biochemical pathways

Folates participate in the one-carbon metabolism (OCM) cycle, supporting many biochemical pathways. Existing methods to profile folate are limited in the diversity of vitamers they measure and the samples they profile. We present a metabolomics workflow for stable extraction, separation, and meas...

2026-02-10 | MTBLS13484 | MetaboLights
TranscriptomicsGene-expression profile of human embryonic germ cells
Gene-expression profile of human embryonic germ cells (EGCs), primordial germ cells (PGCs), embryonal carcinoma cells (ECCs), pluripotent embryonic stem cells (ESCs) and induced pluripotent stem cells (IPSCs)
ORGANISM(S): Homo sapiens 
2018-06-28 | E-MTAB-6851 | biostudies-arrayexpress
TranscriptomicsFunctional diversity and convergence of small non-coding RNAs in male germ cell differentiation and fertilization (mRNA analysis)
The small non-coding RNAs (sncRNAs) are considered as postranscriptional key regulators of male germ cell development. In addition to microRNAs (miRNAs) and PIWI-interacting RNAs (piRNAs), other sncRNAs generated from small nucleolar RNAs (snoRNAs), tRNAs or rRNAs processing may also play important ...
ORGANISM(S): Mus musculus 
2015-03-26 | E-GEOD-59252 | biostudies-arrayexpress
TranscriptomicsNANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice1, where its precise role is yet unclear2-4. We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/Act...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71933 | biostudies-arrayexpress
TranscriptomicsIdentification of genes specific to mouse primordial germ cells through dynamic global gene expression
The molecular mechanisms underlying the commitment of cells to the germ cell lineage and the subsequent formation of germ cells during mammalian development remain poorly understood due to an inability to obtain sufficient amounts of cellular materials to conduct thorough in-vitro analyses. Although...
ORGANISM(S): Mus musculus 
2010-11-16 | E-GEOD-23322 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing of mouse germ cells
Spermatogenesis is a recurring differentiation process that results in the production of male gametes within the testes. During this process, spermatogonial stem cells differentiate to form spermatocytes, which undergo two rounds of meiotic division to form haploid spermatids. Throughout spermiogene...
ORGANISM(S): Mus musculus 
2019-01-25 | E-MTAB-6946 | biostudies-arrayexpress
OtherForty-Four Novel Protein-Coding Loci Discovered Using a Proteomics Informed by Transcriptomics (PIT) Approach in Rat Male Germ Cells.
Data from ProteomeXchange, PXD ID: PXD000872. File: SPC_exc02_compil.msf.mgf. Published as part of Biol Reprod. 2014 Sep 10 . From the Abstract: {{i}} Spermatogenesis is a complex process, dependent upon the successive activation and/or repression of thousands of gene products, and ends with the pr...
ORGANISM(S): Mus_musculus_viruses,rattus_norvegicus_papillomavirus_1_ees_2009_uid40233,rat_coronavirus_parker_uid39313, Rat 
GPM32320003462 | GPMDB
Resource Reanalysis 
GenomicsNANOG alone induces germ cells in primed epiblast in vitro by activation of enhancers [ChIP-seq]
Nanog, a core pluripotency factor in the inner cell mass of blastocysts, is also expressed in unipotent primordial germ cells (PGC) in mice1, where its precise role is yet unclear2-4. We investigated this in an in vitro model, where naïve pluripotent embryonic stem cells (ESCs) cultured in bFGF/Act...
ORGANISM(S): Mus musculus 
2016-01-11 | E-GEOD-71932 | biostudies-arrayexpress
TranscriptomicsPRC1 coordinates timing of sexual differentiation of female primordial germ cells (RNA-Seq)
In mammals, sex differentiation of primordial germ cells (PGCs) is determined by extrinsic cues from the environment1. In female PGCs, expression of Stimulated by retinoic acid 8 (Stra8) and meiosis are induced in response to retinoic acid (RA) provided by the mesonephroi2-4. Given the widespread ro...
ORGANISM(S): Mus musculus 
2013-03-14 | E-GEOD-42852 | biostudies-arrayexpress
Metabolomics1H NMR metabolite monitoring during the differentiation of human induced pluripotent stem cells provides new insights into the molecular events that regulate embryonic chondrogenesis
The integration of cell metabolism with signalling pathways, transcription factor networks and epigenetic mediators is critical in coordinating molecular and cellular events during embryogenesis. Induced pluripotent stem cells (IPSCs) are an established model for embryogenesis, germ layer specificat...
2023-05-24 | MTBLS4854 | MetaboLights
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