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TranscriptomicsGlobal Differential Gene Expression Analysis of Spontaneous Lung Tumors in B6C3F1 Mice: Comparison to Human Non-Small Cell Lung Cancer
Introduction: Lung cancer is the leading cause of cancer-related death in people. There are several chemically induced and genetically modified mouse models used to study lung cancer. We hypothesized that spontaneous murine (B6C3F1) lung tumors can serve as a model to study human non-small cell lung...
ORGANISM(S): Mus musculus 
2012-06-21 | E-GEOD-31013 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression profiling of spontaneous hepatocellular carcinoma in B6C3F1 mice: Similarities in the molecular landscape to human liver cancer.
Hepatocellular carcinoma (HCC) is an important cause of morbidity and mortality worldwide. Although the risk factors of human HCC are well known, the molecular characterization of this disease is complex, and treatment options in general remain poor. The use of rodent models to study human cancer ha...
ORGANISM(S): Mus musculus 
2011-06-06 | E-GEOD-26538 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of rat heart tissue treated with saline or doxorubicin to identify molecular mechanisms of doxorubicin cardiac toxicity
Doxorubicin induces cardiomypathy in oncology patients. This study is aimed at identifying molecular mechanisms of doxorubicin cardiac toxicity in rats. Transcription profiling of heart tissue of rats treated with saline or doxorubicin 1, 2 or 3 mg/kg/week by iv once per week for 2, 4 or 6 weeks. So...
ORGANISM(S): Rattus norvegicus 
2012-07-01 | E-MTAB-1168 | biostudies-arrayexpress
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
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