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TranscriptomicsGenistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of binding sites in a cell type-specific manner
To obtain an integrated view of gene regulation in response to environmental and endogenous estrogens on a genome-wide scale, we performed ChIP-seq, to identify estrogen receptor 1 (ER) binding sites, and RNA-seq in endometrial cancer cells exposed to bisphenol A (BPA; found in plastics), genistein ...
ORGANISM(S): Homo sapiens 
2012-06-13 | E-GEOD-38234 | biostudies-arrayexpress
TranscriptomicsTransposon-based construction of strand-specific RNA-seq libraries
We have developed two methods for efficiently consructing RNA-seq libraries using transposition. Each method constructs high quality RNA-seq libraries when compared to standard approaches. One of the methods (Directional Tn-RNA-seq) maintains strand-of-origin information and exhibits strand specifi...
ORGANISM(S): Homo sapiens 
2011-10-10 | E-GEOD-32307 | biostudies-arrayexpress
GenomicsAnalysis of DNA methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation
To assess variation and inheritance of genome-wide patterns of DNA methylation simultaneously in humans, we applied reduced representation bisulfite sequencing (RRBS) to somatic DNA from six members of a three-generation family. Reduced representation bisulfite sequencing was applied to genomic DNA ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-30253 | biostudies-arrayexpress
GenomicsIKK-epsilon regulates the balance between the type I and type II interferon responses
Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, S...
ORGANISM(S): Mus musculus 
2011-12-01 | E-GEOD-33913 | biostudies-arrayexpress
GenomicsDNA Methylation by Reduced Representation Bisulfite Seq from ENCODE/HudsonAlpha
This data was generated by ENCODE. If you have questions about the data, contact the submitting laboratory directly (Florencia Pauli mailto:fpauli@hudsonalpha.org). If you have questions about the Genome Browser track associated with this data, contact ENCODE (mailto:genome@soe.ucsc.edu). This trac...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-27584 | biostudies-arrayexpress
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