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ProteomicsProteomic Consequences of the Deletion of Cytochrome P450 (CYP450) Reductase in Mice
Microsomal cytochrome P450 (CYP450) reductase enzymes play a major role in drug and xenobiotic metabolism. Mice which are deficient in hepatic CYP450 reductase serve as excellent models in understanding CYP450 drug metabolism and alterations in the underlying biology. A reversed-phase nano-bore UPLC...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-26 | PXD024420 | Pride
Proteomics  cytochrome p450  lipid metabolism  bile acids  glutathione Tca cycle. 
ProteomicsMulti-omic diagnostics of prostate cancer in the presence of benign prostatic hyperplasia
There is an unmet need for improved diagnostic testing and risk prediction for cases of prostate cancer (PCa) to improve care and reduce overtreatment of indolent disease. Here we have analysed the serum proteome and lipidome of 262 study participants by liquid chromatography-mass spectrometry, incl...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD046530 | Pride
Ion mobility Dia Prostate cancer Multi-omics 
ProteomicsMicrobore High Throughput Ion Mobility Enabled Mass Spectrometry for Utilisation of Large Cohort Studies
The deployment of proteomic analysis in clinical studies represents a significant opportunity to detect and validate biomarkers in translational medicine, improve disease understanding and provide baseline information on population health. However, comprehensive proteome studies usually employ nano...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-05-26 | PXD021927 | Pride
Microbore high-throughput ion mobility 
ProteomicsRhythmic variation in proteomics: challenges and opportunities for statistical power and biomarker identification
Time-of-day variation in the molecular profile of biofluids and ssues is a well-described phenomenon, but – especially for proteomics – is rarely considered in terms of the challenges this presents to reproducible biomarker identification. In this work we demonstrate these confounding issues using a...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055555 | Pride
Circadian rhythm dia qtof biomarkers 
UnknownToxicity of ZnO and TiO2 to Escherichia coli cells.
Not available
S-EPMC5378928 | biostudies-literature
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