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MetabolomicsA data integration multi-omics approach to study calorie restriction-induced changes in insulin sensitivity
The mechanisms responsible for weight loss-induced improvement in insulin sensitivity are partially understood. Greater insight can now be achieved through deep phenotyping and data integration. Here, we used an integrative approach to investigate associations between changes in insulin sensitivity ...
2021-02-11 | MTBLS653 | MetaboLights
TranscriptomicsDerivation of rat induced pluripotent stem cells that share similarities with embryonic stem cells using a transposon system
Induced pluripotent stem (IPS) cells have attracted enormous attention due to their vast potential in regenerative medicine, pharmaceutical screening and basic research. The majority of prior established rat IPS cells were generated from somatic cells by retroviral and lentiviral transduction with e...
ORGANISM(S): Rattus norvegicus 
2012-02-16 | E-GEOD-35841 | biostudies-arrayexpress
TranscriptomicsMapping genetic modifiers of ARPKD
Autosomal recessive polycystic kidney disease (ARPKD) is caused by mutations in the PKHD1 gene in both humans and the orthologous PCK rat model. Although ARPKD results solely from PKHD1 mutations, the disease onset and severity are highly variable, indicating that other unknown genetic risk factor(s...
ORGANISM(S): Rattus norvegicus 
2015-06-06 | E-GEOD-58229 | biostudies-arrayexpress
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