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TranscriptomicsChronic Hypoxia predicts Poor Prognosis in Hepatocellular Carcinoma
Background - Hepatocellular carcinomas (HCCs) are heterogeneous tumors with respect to etiology, cell of origin and biology. The course of the disease is unpredictable and is in part dependent on the tumor microenvironment. One of the microenvironmental factors is hypoxia, which is known to promote ...
ORGANISM(S): Homo sapiens 
2010-07-20 | E-GEOD-15366 | biostudies-arrayexpress
TranscriptomicsIntrinsic Gene Expression Profiles of Gliomas are a Better Predictor of Survival than Histology
Histological classification of gliomas guides treatment decisions. Because of the high interobserver variability, we aimed to improve classification by performing gene expression profiling on a large cohort of glioma samples of all histological subtypes and grades. The seven identified intrinsic mol...
ORGANISM(S): Homo sapiens 
2010-04-26 | E-GEOD-16011 | biostudies-arrayexpress
ProteomicsA preclinical platform for assessing long-term drug efficacy exploiting mechanically tunable scaffolds colonized by a three-dimensional tumor microenvironment
Background: Long-term drug evaluation heavily relies upon rodent models. Drug discovery methods to reduce animal models in oncology may include three-dimensional (3D) cellular systems that take into account tumor microenvironment (TME) cell types and biomechanical properties. Methods: In this study...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD039590 | Pride
3d cancer model  long-term  drug evaluation  pre-clinical  micro-environment  stiffness 
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