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GenomicsThe yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
Background: Repair of DNA damage requires chromatin remodeling to permit removal of the lesions. How nucleosomes are remodelled to initiate repair of DNA damage remains largely unknown. Here, we describe how chromatin is altered during repair of UV-induced DNA damage at the level of the linear organ...
ORGANISM(S): Saccharomyces cerevisiae 
2018-12-06 | E-MTAB-6569 | biostudies-arrayexpress
TranscriptomicsDNA repair and recovery of RNA synthesis following exposure to ultraviolet light are delayed in long genes
The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irradiation were assessed using nascent RNA Bru-seq and quantitative long PCR. It was found that UV light inhibited transcription elongation and that recovery of RNA synthesis occurred as a wave in the 5’-3’ direction ...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-65985 | biostudies-arrayexpress
GenomicsThe yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
The yeast GG-NER complex evicts histone H2A.Z-containing barrier nucleosomes from CID boundaries during DNA repair
PRJEB25412 | ENA
Genomics
ASH1L methyltransferase impact on GG-NER
PRJNA872306 | ENA
UnknownSynergistic effects of H3 and H4 nucleosome tails on structure and dynamics of a lesion-containing DNA: Binding of a displaced lesion partner base to the H3 tail for GG-NER recognition.
Not available
S-EPMC5911426 | biostudies-literature
TranscriptomicsGlobal Genome-Nucleotide Excision Repair is Organised into Domains Promoting Efficient DNA Repair in Chromatin
The rates at which lesions are removed by DNA repair can vary widely throughout the genome with important implications for genomic stability. We measured the distribution of nucleotide excision repair (NER) rates for UV induced lesions throughout the yeast genome. By plotting these repair rates in r...
ORGANISM(S): Saccharomyces cerevisiae 
2016-07-21 | E-MTAB-4641 | biostudies-arrayexpress
OtherUV damage mapping reveals different impacts of XPD mutations on global genomic and transcription-coupled DNA repair
Nucleotide Excision Repair (NER) removes bulky DNA lesions, such as ultraviolet (UV) light-induced cyclobutane pyrimidine dimers (CPDs) by utilizing two subpathways: Transcription-Coupled NER (TC-NER) and Global Genomic NER (GG-NER). XPD is a DNA helicase in the transcription factor IIH (TFIIH) comp...
ORGANISM(S): Saccharomyces cerevisiae 
2026-08-31 | GSE334098 | GEO
TranscriptomicsRemoval of oxaliplatin- and cisplatin-DNA lesions requires different global genome repair mechanisms that affect their clinical efficacy.
The therapeutical efficacy of cisplatin and oxaliplatin depends on the balance between the DNA damage induction and the DNA damage response of tumor cells. Based on clinical evidence, oxaliplatin is administered to cisplatin-unresponsive cancers, but the underlying molecular causes for this tumor sp...
ORGANISM(S): Homo sapiens 
2023-12-14 | GSE227871 | GEO
OtherElf1 promotes TC-NER in yeast by using its C-terminal domain to bind TFIIH
Transcription coupled-nucleotide excision repair (TC-NER) repairs DNA lesions that stall RNA polymerase II (Pol II) transcription. Here, we show that the C-terminal domain (CTD) of elongation factor-1 (Elf1) plays a critical role in TC-NER in yeast. Analysis of genome-wide repair of UV-induced cyclo...
ORGANISM(S): Saccharomyces cerevisiae 
2024-05-31 | GSE243603 | GEO
OtherUVDE-seq mapping of UV-induced non-CPD lesions
Here we have used a novel high-throughput sequencing method known as UVDE-seq to map the formation of non-CPD lesions at single nucleotide resolution across the yeast genome in wild-type and rad16 mutant cells, which are deficient in GG-NER.
ORGANISM(S): Saccharomyces cerevisiae 
2020-11-19 | GSE144679 | GEO
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