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TranscriptomicsHypoxic pulmonary hypertension study
These microarray studies were performed using whole lungs of BALB/C mice during development of hypoxia-induced pulmonary hypertension (days 1-21) and resolution of pulmonary hypertension after return to normoxia (days 22-35) . Mice were sampled during nine time-points and each time-point was replic...
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-1909 | biostudies-arrayexpress
TranscriptomicsAge Dependent Gene Expression Responses to Inhaled Lipopolysaccharide Combined with Mechanical Ventilation
Children have a lower incidence and mortality from acute lung injury than adults, and infections are the most common event associated with acute lung injury (ALI). To study the effects of age on susceptibility to ALI, we investigated the responses to microbial products combined with mechanical vent...
ORGANISM(S): Mus musculus 
2009-11-23 | E-GEOD-18341 | biostudies-arrayexpress
TranscriptomicsTranscriptional profile of WT and Mmp10-/- bone marrow-derived macrophages after infection with Pseudomonas aeruginosa
Several members of the matrix metalloproteinase (MMP) family control specific immune processes, such as leukocyte influx and chemokine activity. Stromelysin-2 (MMP10) is expressed in numerous tissues after injury; however, little is known of its function. Here, we report that MMP10 is expressed by m...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-78175 | biostudies-arrayexpress
TranscriptomicsAcute Lung Injury In Experimental Malaria
Although respiratory distress is a common complication of severe malaria, little is known about the underlying molecular basis of lung dysfunction. Animal models have provided powerful insights into the pathogenesis of severe malaria syndromes such as cerebral malaria; however, no model of malaria-i...
ORGANISM(S): Mus musculus 
2010-05-26 | E-GEOD-9497 | biostudies-arrayexpress
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