The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
In this current study, we aimed to produce and develop an affinity matrix for enzymes involved in the folate metabolism of kinetoplastids, effectively the “folateome”folateome of these parasites. This information will then be used to determine the molecular targets of compounds targeting folate meta...
In this current study, we aimed to produce and develop an affinity matrix for enzymes involved in the folate metabolism of kinetoplastids, effectively the “folateome”folateome of these parasites. This information will then be used to determine the molecular targets of compounds targeting folate meta...
In this current study, we aimed to produce and develop an affinity matrix for enzymes involved in the folate metabolism of kinetoplastids, effectively the “folateome”folateome of these parasites. This information will then be used to determine the molecular targets of compounds targeting folate meta...
In this current study, we aimed to produce and develop an affinity matrix for enzymes involved in the folate metabolism of kinetoplastids, effectively the “folateome”folateome of these parasites. This information will then be used to determine the molecular targets of compounds targeting folate meta...
In this current study, we aimed to produce and develop an affinity matrix for enzymes involved in the folate metabolism of kinetoplastids, effectively the “folateome”folateome of these parasites. This information will then be used to determine the molecular targets of compounds targeting folate meta...
Kerkhoven2013 - Glycolysis in T.brucei - MODEL A
There are six models (Model A, B, C, C-fruc, D, D-fruc) described in the paper. Model A ( BIOMD0000000513
) is the model developed originally by Achar et al. (2012) ( BIOMD0000000428
), which des...
Kerkhoven2013 - Glycolysis and Pentose Phosphate Pathway in T.brucei - MODEL B
There are six models (Model A, B, C, C-fruc, D, D-fruc) described in the paper. Model A ( BIOMD0000000513
) is the model developed originally by Achar et al. (2012) ( BIOMD00000...
Kerkhoven2013 - Glycolysis and Pentose Phosphate Pathway in T.brucei - MODEL C in fructose medium (with glucosomal ribokinase)
There are six models (Model A, B, C, C-fruc, D, D-fruc) described in the paper. Model A ( BIOMD0000000513
) is the model developed origi...
Kerkhoven2013 - Glycolysis and Pentose Phosphate Pathway in T.brucei - MODEL D in fructose medium (with ATP:ADP antiporter)
There are six models (Model A, B, C, C-fruc, D, D-fruc) described in the paper. Model A ( BIOMD0000000513
) is the model developed original...
