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ProteomicsMonobromobimane labelling in early- and late-passage primary human mesemchymal stem cells subjected to 2 hour heat shock
Monobromobimane (mBBr) labelling: mBBr labelling was carried out either immediately prior to 42°C, two hour heat shock, or immediately following heat shock. Medium was removed from culture flasks and cells were washed using PBS. Cells were then labelled by incubation at 37°C with 6 mL of 400 µM mBBr...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD025329 | Pride
Human senescent heat shock msc mesenchymal stem cell monobromobimane mbbr 
ProteomicsHSPA1A inhibition in early- and late-passage primary human mesemchymal stem cells subjected to 2 hour heat shock
Cells respond to stress by synthesising chaperone proteins that correct protein misfolding to maintain function. However, protein homeostasis is lost in ageing, leading to aggregates characteristic of protein-folding diseases. Whilst much is known about how these diseases progress, discovering what ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD025305 | Pride
Human senescent heat shock msc mesenchymal stem cell hsp70 inhibition hspa1a 
ProteomicsEarly- and late-passage primary human mesemchymal stem cells subjected to 2 hour heat shock
Cells respond to stress by synthesising chaperone proteins that correct protein misfolding to maintain function. However, protein homeostasis is lost in ageing, leading to aggregates characteristic of protein-folding diseases. Whilst much is known about how these diseases progress, discovering what ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-15 | PXD025280 | Pride
Human senescent heat shock msc mesenchymal stem cell 
ProteomicsHSP90 inhibition in early-passage primary human mesenchymal stem cells subjected to 2 hour heat shock (4 donors)
Cells respond to stress by synthesising chaperone proteins that correct protein misfolding to maintain function. However, protein homeostasis is lost in ageing, leading to aggregates characteristic of protein-folding diseases. Whilst much is known about how these diseases progress, discovering what ...
ORGANISM(S): Homo sapiens (Human) 
2021-07-06 | PXD027056 | Pride
Human Bone marrow Heat shock Mesenchymal stem cells Lc-ms/ms 
UnknownDiscovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
Not available
S-EPMC5601362 | biostudies-literature
UnknownPreclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Not available
S-EPMC6511062 | biostudies-literature
UnknownIdentification of GSK3186899/DDD853651 as a Preclinical Development Candidate for the Treatment of Visceral Leishmaniasis.
Not available
S-EPMC6407917 | biostudies-literature
GenomicsATD
WTCCC1 project Autoimmune Thyroid Disease (ATD) samples
EGAD00000000011 | EGA
GenomicsBC
WTCCC1 project Breast cancer (BC) samples
EGAD00000000013 | EGA
GenomicsMS
WTCCC1 project Multiple Sclerosis (MS) samples
EGAD00000000012 | EGA
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