Sort   by:  
 Page size 
UnknownPhase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors.
Not available
S-EPMC3138720 | biostudies-literature
UnknownPhase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.
Not available
S-EPMC3179253 | biostudies-literature
UnknownVismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.
Not available
S-EPMC4534527 | biostudies-literature
TranscriptomicsTranscription profiling of human and mouse ependymomas: Comparative genomics matches mutations and cells to generate faithful ependymoma models
Genomic technologies have unmasked molecularly distinct subgroups among tumors of the same histological type; but understanding the biologic basis of these subgroups has proved difficult since their defining alterations are often numerous, and the cellular origins of most cancers remain unknown. We...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-21687 | biostudies-arrayexpress
TranscriptomicsA mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]
Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures This study contrasts mouse medullablastomas from a range of mouse genetic models. For Shh-type medulloblastoma [dka001-005, 009, 033 and 034] and [dka050-057], spontaneous medulloblastom...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33199 | biostudies-arrayexpress
TranscriptomicsA mouse model of the most aggressive subgroup of human medulloblastoma [HT_MG-430_PM]
A series of mouse models designed to mimic pediatric medulloblastoma types in humans were tested by microarray and compared to published human medulloblastoma data Myc-type tumors [dka201-203] were generated by orthotopic injection of Myc-infected cerebellar cells from Cdkn2c-/-, Trp53-/-, Atoh1-GFP...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33200 | biostudies-arrayexpress
TranscriptomicsHigh-resolution copy number analysis of medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genome of 212 medulloblastomas, a malignant pediatric brain tumor. Focal amplifications of fifteen known oncogenes and focal deletions of twenty known tumor suppressor genes (TSG) were revealed, most not prev...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-14437 | biostudies-arrayexpress
TranscriptomicsNovel mutations target distinct subgroups of medulloblastoma.
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. To identify mutations that drive medulloblastoma we sequenced the entire genomes of 37 tumours and matched normal blood. One hundred and thirty-six genes harbouring somatic mutations in this discovery set wer...
ORGANISM(S): Homo sapiens 
2012-07-05 | E-GEOD-37418 | biostudies-arrayexpress
GenomicsThe Genomic Analysis of Medulloblastoma

Medulloblastoma is a heterogenous disease made up of at least four distinct subtypes of disease which appear to exploit and disrupt naturally occurring developmental pathways of cellular growth and hindbrain development. To better understand the driver mutations of this disease, we performed whol...

phs000409.v1.p1 | EGA
GenomicsPCGP MB WGS Full - samples
DATA FILES FOR PCGP MB WGS - Supersedes (EGAD00001000269)
EGAD00001001864 | EGA
Sort   by:  
 Page size