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UnknownPhase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumors.
Not available
S-EPMC3138720 | biostudies-literature
TranscriptomicsTranscription profiling of human and mouse ependymomas: Comparative genomics matches mutations and cells to generate faithful ependymoma models
Genomic technologies have unmasked molecularly distinct subgroups among tumors of the same histological type; but understanding the biologic basis of these subgroups has proved difficult since their defining alterations are often numerous, and the cellular origins of most cancers remain unknown. We...
ORGANISM(S): Homo sapiens 
2010-07-19 | E-GEOD-21687 | biostudies-arrayexpress
TranscriptomicsInduction of hepatocellular carcinoma through activation of stromal cells in Pdgf-c transgenic mice
Liver cirrhosis is a strong risk factor for the development of hepatocellular carcinoma (HCC), yet the mechanisms by which cirrhosis predisposes patients to tumorigenesis are not well understood. Transgenic mice expressing platelet-derived growth factor C (Pdgf-c) under the control of the albumin pr...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-38199 | biostudies-arrayexpress
TranscriptomicsA mouse model of the most aggressive subgroup of human medulloblastoma [Mouse430_2]
Mouse models of medulloblastoma are compared to human subgroups through microarray expression and other measures This study contrasts mouse medullablastomas from a range of mouse genetic models. For Shh-type medulloblastoma [dka001-005, 009, 033 and 034] and [dka050-057], spontaneous medulloblastom...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33199 | biostudies-arrayexpress
TranscriptomicsA mouse model of the most aggressive subgroup of human medulloblastoma [HT_MG-430_PM]
A series of mouse models designed to mimic pediatric medulloblastoma types in humans were tested by microarray and compared to published human medulloblastoma data Myc-type tumors [dka201-203] were generated by orthotopic injection of Myc-infected cerebellar cells from Cdkn2c-/-, Trp53-/-, Atoh1-GFP...
ORGANISM(S): Mus musculus 
2012-02-29 | E-GEOD-33200 | biostudies-arrayexpress
TranscriptomicsCritical role for the DNA receptor AIM2 in stem-cell proliferation and cancer
Colorectal cancer is a leading cause of cancer-related deaths. Mutations in the innate immune receptor AIM2 are frequently identified in patients with colorectal cancer, but how AIM2 modulates colonic tumorigenesis is unknown. Here, we found that Aim2-deficient mice were hypersusceptible to colonic ...
ORGANISM(S): Mus musculus 
2015-07-15 | E-GEOD-69436 | biostudies-arrayexpress
TranscriptomicsHigh-resolution copy number analysis of medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the genome of 212 medulloblastomas, a malignant pediatric brain tumor. Focal amplifications of fifteen known oncogenes and focal deletions of twenty known tumor suppressor genes (TSG) were revealed, most not prev...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-14437 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons
The dataset consists of single-cell RNA sequencing (scRNA-seq) profiles of fetal human cortical neurons (10 weeks gestation) under six experimental conditions: Sample 1 – Control: Untreated cells. Sample 2 – PFF treated: Cells exposed to alpha-synuclein pre-formed fibrils (PFF) for 14 days. Sample 3...
ORGANISM(S): Homo sapiens 
2026-04-09 | E-MTAB-16863 | biostudies-arrayexpress
GenomicsPCGP Germline WXS - samples
PCGP Germline Study Whole Exome Sequencing
EGAD00001001433 | EGA
GenomicsPCGP CONSERTING WGS - samples
Data files for CONSERTING (WGS)
EGAD00001001352 | EGA
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