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TranscriptomicsRandom monoallelic expression in the mouse: SNP array data
Random monoallelic expression is defined by the allele-specific expression of genes, and by the fact that for an individual cell this monoallelic expression is neither obligate nor necessarily coordinated with the allelic expression in other cells. In order to find novel examples of random monoallel...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-35678 | biostudies-arrayexpress
TranscriptomicsChromatin signature identifies monoallelic gene expression across mammalian cell types (RNA-seq)
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE, and d...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67379 | biostudies-arrayexpress
GenomicsChromatin signature identifies monoallelic gene expression across mammalian cell types (ChIP-seq)
Monoallelic expression of autosomal genes (MAE) is a widespread epigenetic phenomenon which is poorly understood, due in part to current limitations of genome-wide approaches for assessing it. Recently, we reported that a specific histone modification signature is strongly associated with MAE, and d...
ORGANISM(S): Mus musculus 
2015-06-17 | E-GEOD-67380 | biostudies-arrayexpress
GenomicsDerivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
The presence of two active X chromosomes (XaXa) is a hallmark of the ground state of pluripotency specific to murine embryonic stem cells (ESCs). Human ESCs invariably exhibit signs of X chromosome inactivation (XCI) and are considered developmentally more advanced than their murine counterparts. W...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-21141 | biostudies-arrayexpress
TranscriptomicsSomatic cell fusions reveal extensive heterogeneity in basal-like breast cancer [SNP]
Basal-like and luminal breast tumors have distinct clinical behavior and molecular profiles, yet the underlying mechanisms are poorly defined. To interrogate processes that determine these distinct phenotypes and their inheritance pattern, we generated somatic cell fusions and performed integrated g...
ORGANISM(S): Homo sapiens 
2015-06-10 | E-GEOD-39412 | biostudies-arrayexpress
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