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TranscriptomicsExpression data of ALDH+ breast cancer cells
It has been suggested that breast cancers are driven and maintained by a cellular subpopulation with stem cell properties. These breast cancer stem cells (BCSCs) mediate metastasis and by virtue of their resistance to radiation and chemotherapy, contribute to relapse. Although several BCSC markers ...
ORGANISM(S): Homo sapiens 
2013-11-14 | E-GEOD-52327 | biostudies-arrayexpress
TranscriptomicsmiR-600 acts as a bimodal switcher that regulates breast cancer stem cell fate through WNT signaling
Breast cancer stem cells (bCSCs) have been implicated in tumor progression and therapeutic resistance; however, the molecular mechanisms that define bCSC-state are unclear. We have performed concurrent human miRNome-wide gain- and loss-of-function screens to identify switcher miRNAs controling the c...
ORGANISM(S): Homo sapiens 
2020-08-25 | E-MTAB-5393 | biostudies-arrayexpress
UnknownCD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism.
Not available
S-EPMC8666665 | biostudies-literature
Transcriptomicsbreast cancer cell lines ALDH+/-
Self-renewal and differentiation are two epigenetic programs that regulate pluripotency of stem cells. During oncogenesis, dysregulation of these two programs leads to the development of cancer stem cells (CSCs). Here, we used a pan genomic promoter microarray to determine the DNA methylation portra...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-MTAB-2236 | biostudies-arrayexpress
UnknownProduction of CRISPRi-engineered primary human mammary epithelial cells with baboon envelope pseudotyped lentiviral vectors.
Not available
S-EPMC9871349 | biostudies-literature
UnknownmiRViz: a novel webserver application to visualize and interpret microRNA datasets.
Not available
S-EPMC7319447 | biostudies-literature
UnknownRegulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling.
Not available
S-EPMC2683567 | biostudies-literature
UnknownBRCA1 regulates human mammary stem/progenitor cell fate.
Not available
S-EPMC2234204 | biostudies-literature
ProteomicsCD44 regulates epigenetic plasticity by mediating iron endocytosis - part 1
The biological process termed Epithelial-to-Mesenchymal Transition (EMT) plays a central role in cancer cell invasion, metastasis, self-renewal and resistance to therapy. Here, we characterize using quantitative LC-MS/MS the global changes in proteins levels occurring during EMT induced by epidermal...
ORGANISM(S): Homo sapiens (Human) 
2019-10-01 | PXD011447 | Pride
Emt Breast cancer Proteins expression Lc-ms/ms 
UnknownA stem cell population at the anorectal junction maintains homeostasis and participates in tissue regeneration.
Not available
S-EPMC8115161 | biostudies-literature
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