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TranscriptomicsmiR-600 acts as a bimodal switcher that regulates breast cancer stem cell fate through WNT signaling
Breast cancer stem cells (bCSCs) have been implicated in tumor progression and therapeutic resistance; however, the molecular mechanisms that define bCSC-state are unclear. We have performed concurrent human miRNome-wide gain- and loss-of-function screens to identify switcher miRNAs controling the c...
ORGANISM(S): Homo sapiens 
2020-08-25 | E-MTAB-5393 | biostudies-arrayexpress
TranscriptomicsExpression data of ALDH+ breast cancer cells
It has been suggested that breast cancers are driven and maintained by a cellular subpopulation with stem cell properties. These breast cancer stem cells (BCSCs) mediate metastasis and by virtue of their resistance to radiation and chemotherapy, contribute to relapse. Although several BCSC markers ...
ORGANISM(S): Homo sapiens 
2013-11-14 | E-GEOD-52327 | biostudies-arrayexpress
TranscriptomicsA stemness-related ZEB1-MSRB3 axis governs cellular pliancy and cancer genome stability.
Genomic instability is a prominent driver of tumorigenesis. However, a significant fraction of human cancers display few genomic aberrations, suggesting alternative roads towards malignancy. Here, we show that the differentiation status of normal human mammary epithelial cells influences the early r...
ORGANISM(S): Homo sapiens 
2017-03-23 | E-MTAB-4145 | biostudies-arrayexpress
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