Sort   by:  
 Page size 
TranscriptomicsTRAIL/IZI in Melanoma in 2 cell lines A375 and WM1346
parental versus conditioned, IZI versus control
ORGANISM(S): Homo sapiens 
2022-01-12 | E-MTAB-10669 | biostudies-arrayexpress
TranscriptomicsProfiling of the miRNome in melanoma cells under normoxia and hypoxia
The proteomes and the miRNomes of melanoma cells and secreted vesicles of normoxic and hypoxic A375, 501Mel, MelJuso and IPC298 melanoma cells were characterized. Here are the data related to the miRNome of cell extracts for the 4 cell lines, in normoxia and hypoxia conditions.
ORGANISM(S): Homo sapiens 
2020-03-31 | E-MTAB-8577 | biostudies-arrayexpress
TranscriptomicsSingle nuclei chromatin profiles of midbrain from genetically distinct mouse strains reveal cell identity transcription factors and cell type-specific gene regulatory variation
Here we report 20 658 single nuclei chromatin accessibility profiles of ventral midbrain cell types from two genetically diverse and commonly used mouse strains, C57BL6/J and A/J. In total we identify over 260 000 unique accessible sites. The distinct chromatin profiles are consistent with gene expr...
ORGANISM(S): Mus musculus 
2022-01-14 | E-MTAB-9225 | biostudies-arrayexpress
TranscriptomicsPhenotypic differences in dopaminergic circuitries of mouse strains are associated with extensive regulatory variation in the midbrain
The nigrostriatal circuitry in the substantia nigra (SN) exerts control over the motor system and the loss of dopaminergic neurons (DAns) in the SN is the primary cause of Parkinson’s disease (PD). We have performed RNA-seq, ChIP-seq, and ATAC-seq analysis of the ventral midbrains of three widely us...
ORGANISM(S): Mus musculus 
2019-10-07 | E-MTAB-8333 | biostudies-arrayexpress
TranscriptomicsReduced sialylation triggers complement c3-mediated neuronal loss in aging mice
Mice heterozygous for the bifunctional enzyme glucosamine-2-epimerase/N-acetylmannosamine kinase (GNE+/-), which is essential for sialic acid biosynthesis, showed reduced gne transcription and sialylation in different brain regions. We found synapse loss in the hippocampus of GNE+/- mice at 6 months...
ORGANISM(S): Mus musculus 
2019-10-07 | E-MTAB-7790 | biostudies-arrayexpress
TranscriptomicsTemporal enhancer profiling of parallel lineages identifies AHR and GLIS1 as regulators of mesenchymal multipotency
Temporal data on gene expression and context-specific open chromatin states can improve identification of key transcription factors (TFs) and the gene regulatory networks (GRNs) controlling cellular differentiation. However, their integration remains challenging. Here, we delineate a general approac...
ORGANISM(S): Mus musculus 
2019-02-07 | E-MTAB-6840 | biostudies-arrayexpress
Transcriptomics2-hydroxyglutarate modulates histone methylation using both RNA/ChIP-seq
2-hydroxyglutarate (2-HG) is an oncometabolite accumulating in certain cancers and some neurometabolic diseases. In cancers 2-HG accumulation is induced by a gain-of-function mutation in isocitrate dehydrogenase (IDH) genes, leading to conversion of alpha-ketoglutarate (a-KG) into 2-HG
ORGANISM(S): Saccharomyces cerevisiae S288C 
2023-04-15 | E-MTAB-11328 | biostudies-arrayexpress
TranscriptomicsRNA stearic HT29
Investigating the role of fatty acid on HT29 cells in the CRC context
ORGANISM(S): Homo sapiens 
2025-01-01 | E-MTAB-14429 | biostudies-arrayexpress
Sort   by:  
 Page size