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UnknownApolipoproteins L1-6 share key cation channel-regulating residues but have different membrane insertion and ion conductance properties.
The human apolipoprotein L gene family encodes the apolipoprotein L1-6 (APOL1-6) proteins, which are effectors of the innate immune response to viruses, bacteria and protozoan parasites. Due to a high degree of similarity between APOL proteins, it is often assumed that they have similar functions to...
S-EPMC8358165 | biostudies-literature
UnknownApolipoprotein L-1 renal risk variants form active channels at the plasma membrane driving cytotoxicity.
Recently evolved alleles of Apolipoprotein L-1 (APOL1) provide increased protection against African trypanosome parasites while also significantly increasing the risk of developing kidney disease in humans. APOL1 protects against trypanosome infections by forming ion channels within the paras...
S-EPMC7292663 | biostudies-literature
UnknownMachine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score.
Not available
S-EPMC8344569 | biostudies-literature
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