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TranscriptomicsRNA-Seq of murine GIST-like tumors after Etv1 ablation
We used a mouse expressing three alleles 1) KitV558Delta/+ activating allele that develop GIST-like tumors in the cecum, 2) Etv1 flox/flox conditional knockout allele and 3) Rosa26-CreERT2 tamoxifen activated Cre allele. Mice were treated with either Tamoxifen (to delete Etv1) or corn oil (control)....
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-64608 | biostudies-arrayexpress
TranscriptomicsExpression data from SDH-disabled GIST
Pediatric GIST commonly harbors a disabled succinate dehydrogenase complex (SDH), which yields tumors with highly conserved genomes but characteristic epigenomic signatures. Mysteriously, nearly half of such SDH-deficient GIST, including tumors from Carney Triad patients, lack identifiable mutations...
ORGANISM(S): Homo sapiens 
2015-01-02 | E-GEOD-56670 | biostudies-arrayexpress
GenomicsMapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST).
ETV1 is highly expressed in GIST and their presumed precursors--the interstitial cells of Cajal. ETV1 is required for survival for both GIST and ICC and regulates GIST signature genes. Here, using Illumina-Solexa based next-generation sequencing of ETV1 chromatin immunoprecipates (ChIP-Seq), we defi...
ORGANISM(S): Homo sapiens 
2010-10-14 | E-GEOD-22441 | biostudies-arrayexpress
TranscriptomicsDifferences of miRNA expression profiling between GIST and leiomyoma tissue samples acquired by Tunneling Bloc Biopsy
miRNA expression profiling between GIST and leiomyoma specimens taken by Tunneling Bloc Biopsy Nine GIST patients and seven gastric leiomyoma patients underwent endoscopic biopsy called Tunnel Block Biopsy. MiRNAs were extracted from the tissues, then.
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-63453 | biostudies-arrayexpress
TranscriptomicsCopy number data from GIST with KIT mutation
In addition to KIT and PDGFRA mutations, sequential accumulation of other genetic events is involved in the development and progression of gastrointestinal stromal tumors (GISTs). Until recently, the significance of these other alterations has not been thoroughly investigated. The combination of gen...
ORGANISM(S): Homo sapiens 
2010-08-27 | E-GEOD-20709 | biostudies-arrayexpress
TranscriptomicsGastrointestinal stromal tumor GIST: gene expresssion and ChIP analyses
This SuperSeries is composed of the following subset Series: GSE19396: ETV1 knockdown in GIST cell lines GSE22433: Imatinib Treatment of GIST882 GSE22441: Mapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST). Refer to individual Series
ORGANISM(S): Homo sapiens 
2010-10-14 | E-GEOD-22852 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumor (GIST) reveals gene expression determined distinct classes.
GIST is considered to invariably arise through gain-of-function KIT or PDGFRA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GIST is poorly understood. We analysed the expression levels of 54,613 probe sets in 32 surgical samples of untr...
ORGANISM(S): Homo sapiens 
2008-10-18 | E-GEOD-8167 | biostudies-arrayexpress
TranscriptomicsGenome wide analysis of mouse gastrointestinal stromal tumors (GIST) in a mouse model of spontaneous GIST.
Analysis of mouse GIST tumors at the gene expression level. The purpose of the study was to identify immunomodulatory genes in mouse GIST tumors after in vivo treatment with the specific tyrosine kinase inhibitor imatinib mesylate. Total RNA obtained from mouse GIST tumors after in vivo treatment wi...
ORGANISM(S): Mus musculus 
2011-12-31 | E-GEOD-30416 | biostudies-arrayexpress
TranscriptomicsETV1 knockdown in GIST cell lines
ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown. Two GIST cell lines (GIST48 and GIST882) were infected in duplicate with three shRNA virus...
ORGANISM(S): Homo sapiens 
2010-10-13 | E-GEOD-19396 | biostudies-arrayexpress
TranscriptomicsGene expression signatures in GIST-T1 cells transfected with siRNA targeting HOTAIR
To analyze the effect of HOTAIR depletion in a gastrointestinal stromal tumor (GIST) cells, RNAi-mediated knockdown of HOTAIR was carried out using GIST-T1 cells. Gene expression microarray analysis revealed that a number of reported HOTAIR target genes were upregulated by knockdown of HOTAIR. Mor...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-32064 | biostudies-arrayexpress
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