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TranscriptomicsPlatelet RNA-Seq
Platelet-rich plasma (PRP) has been obtained by centrifuging whole blood at 160 g for 15 min at room temperature. Platelets have been activated with 2 different physiologic agonists, namely collagen (60ug/mL) or Thrombin Receptor Activating Peptide (TRAP 25uM) under continuous stirring. An aliquot o...
ORGANISM(S): Homo sapiens 
2015-04-27 | E-MTAB-2355 | biostudies-arrayexpress
TranscriptomicsThe nuclear receptor ERbeta engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Part 2
The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity, and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. The Estrogen Receptor beta (ERβ) is endowed with oncosuppressi...
ORGANISM(S): Homo sapiens 
2016-12-31 | E-MTAB-4639 | biostudies-arrayexpress
TranscriptomicsEstrogen receptor β role in tumour suppression of triple negative breast cancer - ChIPseq experiment
Breast cancer (BC) is the most common cancer in women worldwide, and is classified in multiple subtypes, including the so called triple-negative BC (TNBC). This is characterized by lack of estrogen receptor alpha (ERα), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2/neu), th...
ORGANISM(S): Homo sapiens 
2019-12-02 | E-MTAB-8056 | biostudies-arrayexpress
TranscriptomicsTargeted inhibition of ubiquitin signaling reverses the metabolic reprogramming and suppresses Glioblastoma growth
Glioblastoma (GBM) is the most frequent and aggressive form of primary brain tumor in the adult population, and the high recurrence rate and resistance to current therapeutics urgently demand a better therapy for this disease. Regulation of protein stability by the ubiquitin proteasome system (UPS) ...
ORGANISM(S): Homo sapiens 
2022-06-29 | E-MTAB-11137 | biostudies-arrayexpress
GenomicsThe nuclear receptor ERbeta engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Part 5
The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity, and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. The Estrogen Receptor beta (ERβ) is endowed with oncosuppressi...
ORGANISM(S): Homo sapiens 
2017-04-25 | E-MTAB-4359 | biostudies-arrayexpress
TranscriptomicsThe nuclear receptor ERbeta engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Part 3
The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity, and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. The Estrogen Receptor beta (ERβ) is endowed with oncosuppressi...
ORGANISM(S): Homo sapiens 
2016-12-31 | E-MTAB-4368 | biostudies-arrayexpress
TranscriptomicsFunctionally-relevant splicing of resident pre-mRNAs in anucleate platelets upon activation by physiological stimuli
Platelet activation is the key event triggering thrombus formation in physiological and pathological conditions, such as acute coronary syndromes. Current therapies using antiaggregants still fail to prevent thrombotic coronary events in a significant number of patients, indicating that the mechanis...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-6148 | biostudies-arrayexpress
TranscriptomicsDissecting the peculiar RIZ2 oncogenic properties in colorectal cancer: a link with EGF/EGFR axis
Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5-year survival rate of ~45%. PRDM2/RIZ, a member of Positive Regulatory Domain (PRDM) gene family,...
ORGANISM(S): Homo sapiens 
2023-10-20 | E-MTAB-13103 | biostudies-arrayexpress
TranscriptomicsThe nuclear receptor ERbeta engages AGO2 in regulation of gene transcription, RNA splicing and RISC loading. Part 4
The RNA-binding protein Argonaute 2 (AGO2) is a key effector of RNA-silencing pathways It exerts a pivotal role in microRNA maturation and activity, and can modulate chromatin remodeling, transcriptional gene regulation and RNA splicing. The Estrogen Receptor beta (ERβ) is endowed with oncosuppressi...
ORGANISM(S): Homo sapiens 
2017-04-25 | E-MTAB-4363 | biostudies-arrayexpress
GenomicsHistone ChIPSeq of H3K79me2 before and after EPZ004777 treatment in MCF7 breast cancer cells
Histone ChIPSeq of H3K79me2 before and after EPZ treatment in MCF7 breast cancer cells
ORGANISM(S): Homo sapiens 
2019-02-08 | E-MTAB-6889 | biostudies-arrayexpress
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