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TranscriptomicsmiR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia
MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible mi...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-78078 | biostudies-arrayexpress
TranscriptomicsDistinct myeloid progenitor differentiation pathways uncovered through single cell RNA sequencing
Haematopoietic stem cells can differentiate into all blood cell types. In this process, cells become progressively restricted to a single cell type. The order in which differentiating cells loose lineage potential, and the prospective isolation of cells with a defined potential remains a long-standi...
ORGANISM(S): Mus musculus 
2016-04-04 | E-GEOD-77029 | biostudies-arrayexpress
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