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ProteomicsThe selenoprotein TXNRD3 supports male fertility via the redox regulation of spermatogenesis
Thioredoxin/glutathione reductase (TGR, TXNRD3) is a selenoprotein composed of thioredoxin reductase and glutaredoxin domains; the function of this enzyme remains unknown. This NADPH-dependent thiol oxidoreductase evolved by gene duplication within the Txnrd family, is expressed in the testes and ca...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-13 | PXD033872 | Pride
Redox control Sperm motility Thioredoxin glutathione reductase Male fertility 
TranscriptomicsSelT knockdown mouse fibroblast cells vs control cells
Analysis of gene expression in NIH 3T3 cells stably knockdown for Selt (GenBank accession number NM_001040396) using vector based siRNA technique in comparison to gene expression of vector transfected NIH 3T3 cells. siSelT-1 construct (spanning nucleotides 205-224 of Selt, GenBank accession number N...
ORGANISM(S): Mus musculus 
2010-06-20 | E-GEOD-17087 | biostudies-arrayexpress
TranscriptomicsWild type mice (Trsp) vs Trsp-knockout mice (DTrsp) or A34 or G37L or G37H transgenic mice
Comparative analysis of gene expression in the liver of the Trsp-knockout mice (Trspfl/fl-AlbCre+/+) and A34 (Trspfl/fl-AlbCre+/+-A34t/t), G37L (Trspfl/fl-AlbCre+/+-G37t/t; 2 copies), G37H (Trspfl/fl-AlbCre+/+-G37t/t; 16 copies) transgenic mice with gene expression of wild type mice (Trsp+/+-AlbCre...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-12495 | biostudies-arrayexpress
TranscriptomicsGene Expression Defines Natural Changes in Mammalian Lifespan
Mammals differ more than hundred fold in maximum lifespan, which can be altered in either direction during evolution, but the molecular basis for natural changes in longevity is not understood. Divergent evolution of mammals also led to extensive changes in gene expression within and between lineage...
ORGANISM(S): Bos taurus 
2015-02-17 | E-GEOD-43013 | biostudies-arrayexpress
TranscriptomicsTranscriptome sequencing of naked mole rat, Heterocephalus glaber
Deep sequencing of mRNA from naked mole rat Analysis of ploy(A)+ RNA of different specimens: brain, kidney, liver from new born , 4 years old , 20 years old and 4 years old hypoxia-exposed naked mole rat
ORGANISM(S): Heterocephalus glaber 
2011-10-12 | E-GEOD-30337 | biostudies-arrayexpress
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