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TranscriptomicsThe Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis
Hepatocarcinogenesis is a multi-stage process in which precursor lesions progress into early hepatocellular carcinomas (eHCC) by sequential accumulation of multiple genetic and epigenetic alterations. To decode the molecular events during early stages of liver carcinogenesis, we performed gene expre...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-12443 | biostudies-arrayexpress
TranscriptomicsGlobal genomic mapping, in Saccharomyces cerevisiae, of new suppressor alleles of the RNA polymerase I subunit rpa49 deletion.
In the yeast saccharoryces cerevisiae, RPA49 full-deletion mutants show a strong growth defect at 30°C and are unable to grow at 25°C. However, spontaneous suppressors that restore growth at 25°C are observed. We attend to identified new suppressor alleles after UV treatment. To mapped the genomic l...
ORGANISM(S): Saccharomyces cerevisiae 
2019-12-31 | E-MTAB-7831 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human common melanocytic nevi, radial and vertical growth phase melanomas, melanoma metastases and dysplastic nevi
Despite malignant cutaneous melanoma is relatively rare compared to other skin cancers, it is still responsible for 80% of all skin cancer-related deaths. To identify molecular signatures of melanoma progression, excisional biopsies from 18 common melanocytic nevi (CMN), 8 primary radial growth phas...
ORGANISM(S): Homo sapiens 
2009-10-10 | E-GEOD-12391 | biostudies-arrayexpress
UnknownGraphene Nanoplatelets' Effect on the Crystallization, Glass Transition, and Nanomechanical Behavior of Poly(ethylene 2,5-furandicarboxylate) Nanocomposites.
Not available
S-EPMC9571983 | biostudies-literature
TranscriptomicsSubtype-specific peripheral blood gene expression profiles in recent onset JIA
Objective: A multi-center study of recent onset juvenile idiopathic arthritis (JIA) subjects prior to treatment with DMARDS or biologics was undertaken to identify peripheral blood gene expression differences between JIA subclasses and controls. Methods: PBMC from 59 healthy children and 136 JIA ...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-13501 | biostudies-arrayexpress
TranscriptomicsMultiome snRNA + snATAC on MCF10-2A cells to study how high CENP-A levels promote EMT
CENP-A, the centromeric histone H3 variant, is essential for the proper segregation of human chromosomes to daughter cells. High CENP-A expression leads to the misincorporation of CENP-A in non-centromeric chromatin and can promote an epithelial-mesenchymal transition (EMT). Here, we explored how C...
ORGANISM(S): Homo sapiens 
2026-04-24 | E-MTAB-15582 | biostudies-arrayexpress
TranscriptomicsGene Expression Profiling in Peripheral Blood in Untreated New Onset Systemic Juvenile Idiopathic Arthritis
Systemic Juvenile Idiopathic Arthritis (sJIA) has been strongly associated with macrophage activation syndrome (MAS). To better understand the pathogenesid of sJIA and to facilitate the search for MAS biomarkers, we examine gene expression profiles in untreated new onset sJIA. 17 new onset sJIA pat...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-7753 | biostudies-arrayexpress
GenomicsCENP-A and H3.3 ChIP-seq of MCF10-2A cells to study how high CENP-A levels promote EMT
CENP-A, the centromeric histone H3 variant, is essential for the proper segregation of human chromosomes to daughter cells. High CENP-A expression leads to the misincorporation of CENP-A in non-centromeric chromatin and can promote an epithelial-mesenchymal transition (EMT). Here, we explored how C...
ORGANISM(S): Homo sapiens 
2026-04-24 | E-MTAB-15579 | biostudies-arrayexpress
GenomicsCENP-A ChIP-seq of MCF10-2A cells to study CENP-A localization following reversal from high to basal CENP-A expression
CENP-A, the centromeric histone H3 variant, is essential for the proper segregation of human chromosomes to daughter cells. High CENP-A expression leads to the misincorporation of CENP-A in non-centromeric chromatin and can promote an epithelial-mesenchymal transition (EMT). Here, we explored how C...
ORGANISM(S): Homo sapiens 
2026-04-24 | E-MTAB-16636 | biostudies-arrayexpress
TranscriptomicsExpression Signatures in Polyarticular JIA Show Heterogeneity and Offer a Molecular Classification of Disease Subsets
Objective. Microarray analysis was used to determine whether children with recent onset polyarticular juvenile idiopathic arthritis (JIA) exhibit biologically or clinically informative gene expression signatures in peripheral blood mononuclear cells (PBMC). Methods. Peripheral blood samples were o...
ORGANISM(S): Homo sapiens 
2009-06-30 | E-GEOD-13849 | biostudies-arrayexpress
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