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MetabolomicsFFAR4-mediated IL-6 release from islet macrophages promotes insulin secretion and is compromised in type-2 diabetes

The function of islet macrophages is poorly understood. They promote glucose-stimulated insulin secretion (GSIS) in lean mice, however, the underlying mechanism has remained unclear. We show that activation of the free fatty acid receptor FFAR4 on islet macrophages leads to interleukin-6 (IL-6) r...

2026-08-19 | MTBLS12317 | MetaboLights
TranscriptomicsRNA seq of pancreatic islets isolated from free fatty acid receptor 3 knockout (Ffar3 KO) and wildtype (Ffar3 WT) male mice
The short chain fatty acid (SCFA) receptor (free fatty acid receptor-3; FFAR3) is expressed in pancreatic beta cells; however, its role in insulin secretion is not clearly defined. Here, we examined the role of FFAR3 in insulin secretion. Using islets from global knockout FFAR3 (Ffar3-/-) mice, we e...
ORGANISM(S): Mus musculus 
2016-07-03 | E-GEOD-67991 | biostudies-arrayexpress
ProteomicsAn INS-1 𝛽-cell proteome highlights the role of fatty acid biosynthesis in glucose-stimulated insulin secretion
Pancreatic beta cells secrete insulin as a response to rising glucose levels in the blood, a process that is known as glucose-stimulated insulin secretion (GSIS). Although GSIS has been extensively studied, not all associated mechanisms are fully understood at the molecular level. In this study, we ...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-07 | PXD053750 | Pride
Beta cells Insulin secretion Glucose stimulation Quantitative proteomics 
TranscriptomicsMolecular phenotyping of multiple mouse strains under metabolic challenge uncovers Elovl2 as a novel regulator of glucose-induced insulin secretion
Defective insulin secretion by pancreatic β cells underlies the development of type 2 diabetes (T2D). High fat diet-fed mice are commonly used to study diabetes progression, but studies are usually limited to a single strain, such as C57Bl/6J. Here, we use a systems biology approach to integrate la...
ORGANISM(S): Mus musculus 
2017-04-28 | E-GEOD-78183 | biostudies-arrayexpress
Modelspancreas glucose model
The pancreas plays a critical role in maintaining glucose homeostasis through the secretion of hormones from the islets of Langerhans. Glucose-stimulated insulin secretion (GSIS) by the pancreatic beta-cell is the main mechanism for reducing elevated plasma glucose. Here we present a systematic mode...
2024-01-18 | MODEL2401110001 | BioModels
TranscriptomicsTranscription profiling of wild type and Foxa2 knock out mouse mature beta cells
The winged helix transcription factor Foxa2 regulates Pdx1 gene expression and fetal endocrine pancreas development. We show here by inducible gene ablation that Foxa2 inactivation in mature beta-cells induces hyperinsulinemic hypoglycemia in Foxa2loxP/loxP, Pdx1-CreERT2 adult mice. Mutant beta-cell...
ORGANISM(S): Mus musculus 
2007-09-22 | E-CBIL-39 | biostudies-arrayexpress
GenomicsThe ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice
The ortholog of the Human T2D Risk Gene STEAP2 is Required for Glucose Stimulated Insulin Secretion in Mice
PRJNA1532815 | ENA
GenomicsGDF15 Secretion is Increased in Resposne to Skeletal Muscle Contraction and Potentiates Glucose-Stimulated Insulin Release in Pancreatic β-cells
GDF15 Secretion is Increased in Resposne to Skeletal Muscle Contraction and Potentiates Glucose-Stimulated Insulin Release in Pancreatic β-cells
PRJNA587419 | ENA
GenomicsBeta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion
Beta-cell specific insulin resistance promotes glucose-stimulated insulin hypersecretion
PRJNA669991 | ENA
UnknownPim3 negatively regulates glucose-stimulated insulin secretion.
Not available
S-EPMC3025049 | biostudies-literature
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