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MetabolomicsRedirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Tet3 is the main α-ketoglutarate (αKG)-dependent dioxygenase in neurons that converts 5-methyl-dC into 5-hydroxymethyl-dC and further on to 5-formyl- and 5-carboxy-dC. Neurons possess high levels of 5-hydroxymethyl-dC that further increase during neural activity to establish transcriptional plast...

2021-06-24 | MTBLS2852 | MetaboLights
TranscriptomicsGeneChip expression profiling of Glud1 (glutamate dehydrogenase 1) transgenic mice across age
Glud1 (Glutamate dehydrogenase 1) transgenic mice release more excitatory neurotransmitter glutamate to synaptic cleft throughout lifespan. Here we compared transcriptomic profiles of these animals to their wild-type counterparts across 5 ages. The hippocampus was used for the analysis. Longitudinal...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-48911 | biostudies-arrayexpress
TranscriptomicsGeneChip expression profiling of Glud1 (glutamate dehydrogenase 1) transgenic mice
Glud1 (glutamate dehydrogenase 1) transgenic mice release more excitatory neurotransmitter glutamate to synaptic cleft throughout lifespan and show signs of accelerated aging. Here we compared transcriptomic profiles of these animals to their wild-type counterparts. The hippocampus was used for the ...
ORGANISM(S): Mus musculus 
2010-07-12 | E-GEOD-11419 | biostudies-arrayexpress
MetabolomicsThe prognostic value of hydroxybutyrate dehydrogenase in diffuse large B-cell lymphoma

In our investigation, we examined biochemical parameters and identified hydroxybutyrate dehydrogenase (HBDH) as a significant predictor for diffuse large B-cell lymphoma (DLBCL) patients. A group of 100 patients was used to explore potential biomarkers related to progression-free survival (PFS). ...

2024-09-02 | MTBLS10446 | MetaboLights
MetabolomicsMitochondrial KMT9 methylates DLAT to control pyruvate dehydrogenase activity and prostate cancer growth

Prostate cancer (PCa) growth depends on de novo lipogenesis controlled by the mitochondrial pyruvate dehydrogenase complex (PDC). In this study, we identified lysine methyltransferase (KMT)9 as a novel regulator of PDC activity. KMT9 is localized in mitochondria of PCa cells, but not in mitochond...

2024-12-10 | MTBLS2452 | MetaboLights
MetabolomicsSelective galactose culture condition reveals distinct metabolic signatures in pyruvate dehydrogenase and complex I deficient human skin fibroblasts

INTRODUCTION: A decline in mitochondrial function represents a key factor of a large number of inborn errors of metabolism, which lead to an extremely heterogeneous group of disorders.

OBJECTIVES: To gain insight into the biochemical consequences of mitocho...

2021-10-06 | MTBLS761 | MetaboLights
MetabolomicsUse of Aspartate Dehydrogenase by cancer cells
Not available
ORGANISM(S): Homo sapiens 
ST000154 | MetabolomicsWorkbench
TranscriptomicsRegulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae
Several genes involved in nitrogen metabolism are known to contribute to the virulence of pathogenic bacteria. Here, we studied the function of the nitrogen regulatory protein GlnR in the Gram-positive human pathogen Streptococcus pneumoniae. We demonstrate that GlnR mediates transcriptional repress...
ORGANISM(S): Streptococcus pneumoniae 
2010-07-01 | E-GEOD-5088 | biostudies-arrayexpress
MetabolomicsPlasmodium falciparum stable-isotope carbon labeling to explore metabolic consequences of keto–acid dehydrogenase disruption
Not available
ORGANISM(S): Plasmodium falciparum 
ST002024 | MetabolomicsWorkbench
TranscriptomicsGeneChip expression profiling of Glud1 (glutamate dehydrogenase 1) transgenic mice
Glud1 (glutamate dehydrogenase 1) transgenic mice release more excitatory neurotransmitter glutamate to synaptic cleft throughout lifespan and show signs of accelerated aging. Here we compared transcriptomic profiles of these animals to their wild-type counterparts. The hippocampus was used for the ...
ORGANISM(S): Mus musculus 
2010-07-12 | GSE11419 | GEO
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