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GenomicsGlycolysis involved in transcription dysregulation through histone lactylation in T-lineage acute lymphoblastic leukemia
Glycolysis involved in transcription dysregulation through histone lactylation in T-lineage acute lymphoblastic leukemia
PRJNA1098208 | ENA
GenomicsGlycolysis involved in transcription dysregulation through histone lactylation in T-lineage acute lymphoblastic leukemia II
Glycolysis involved in transcription dysregulation through histone lactylation in T-lineage acute lymphoblastic leukemia II
PRJNA1098754 | ENA
GenomicsGlycolysis involved in transcription dysregulation through histone lactylation in T-lineage acute lymphoblastic leukemia
Tumor cells are known for excessive lactate production, due to Warburg effect, and transcriptional dysregulation. However, how lactate influences the epigenetic modifications at a genome-wide level and its impact on gene transcription in tumor cell remains unclear. Addressing this gap, we analyzed g...
ORGANISM(S): Homo sapiens 
2024-05-31 | GSE263584 | GEO
TranscriptomicsGlycolysis involved in transcription dysregulation through histone lactylation in T-lineage acute lymphoblastic leukemia II
Tumor cells are known for excessive lactate production, due to Warburg effect, and transcriptional dysregulation. However, how lactate influences the epigenetic modifications at a genome-wide level and its impact on gene transcription in tumor cell remains unclear. Addressing this gap, we analyzed g...
ORGANISM(S): Homo sapiens 
2024-05-20 | GSE263697 | GEO
ProteomicsComprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes
Omega-3 polyunsaturated fatty acids (n-3 PUFA), such as the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are reported to beneficially affect intestinal immunity. The intestinal epithelial layer (IEL), made up of absorptive cells as the enterocytes, is the primary site of fatty acid ab...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-12-11 | PXD036456 | Pride
Lipopolysaccharides Lc-ms/ms. Enterocytes Metabolic stress Biological dataset Omega-3 polyunsaturated fatty acids Shotgun proteomics 
UnknownComprehensive proteomic analysis reveals omega-3 fatty acids to counteract endotoxin-stimulated metabolic dysregulation in porcine enterocytes.
Not available
S-EPMC10703801 | biostudies-literature
UnknownInsulin-Like Growth Factors Are Key Regulators of T Helper 17 Regulatory T Cell Balance in Autoimmunity.
Not available
S-EPMC8078727 | biostudies-literature
UnknownBlocking NHE1 stimulates glioma tumor immunity by restoring OXPHOS function of myeloid cells.
Not available
S-EPMC7738877 | biostudies-literature
MetabolomicsSARS-CoV-2 ORF7a Drives Mitochondrial Dysfunction via PDK4 Activation and Complex I Inhibition

SARS-CoV-2 reprograms host metabolism to promote viral replication and evade immune responses. While infection is known to impair mitochondrial function and enhance glycolysis, the role of viral accessory proteins in these alterations remains unclear. Here, we investigate the metabolic impact of ...

2026-07-09 | MTBLS13338 | MetaboLights
UnknownThe dysregulation of metabolic pathways and induction of the pentose phosphate pathway in renal ischaemia-reperfusion injury.
Not available
S-EPMC7986929 | biostudies-literature
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