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Regulatory role of Gnao1 in neuronal differentitation
CRISPR activation screen identifies GNAO1 as a driver of glioblastoma cell differentiation
Pathogenic variations in GNAO1 are associated with developmental and epileptic encephalopathy (DEE). To understand molecular mechanisms underlying GNAO1-associated DEE, we performed a transcriptomic analysis (RNA sequencing) on Neuro2a cells after siRNA-mediated silencing of Gnao1.
ORGANISM(S): Mus musculus 
2024-08-02 | GSE241258 | GEO
Inducing tumor cell differentiation is a potential strategy for treating malignant cancers, including glioma. Here we perform a genome-scale CRISPR activation screen and identify that G Protein Subunit Alpha O1 (GNAO1) as a critical regulator of glioma cell differentiation. GNAO1 overexpression in c...
ORGANISM(S): Homo sapiens 
2026-01-07 | GSE234341 | GEO
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