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UnknownRandomized open-label phase II study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes.
Not available
S-EPMC4878053 | biostudies-literature
TranscriptomicsGenome-wide variation of cytosine modifications between European and African populations and the implications for complex traits
Elucidating cytosine modification difference between human populations can enhance our understanding of ethnic specificity in complex traits such as disease predisposition and drug response. In this study, cytosine modification levels in 133 HapMap lymphoblastoid cell lines (LCLs) derived from indiv...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-39672 | biostudies-arrayexpress
TranscriptomicsDNMT3B7 disrupts embryonic development and accelerates lymphomagenesis
Cancer cells have an altered distribution of DNA methylation and express aberrant DNA methyltransferase 3B transcripts, which encode truncated proteins. To test if a truncated DNMT3B isoform disrupts DNA methylation in vivo, we constructed transgenic mice expressing DNMT3B7, a common truncated DNMT3...
ORGANISM(S): Mus musculus 
2010-07-30 | E-GEOD-21273 | biostudies-arrayexpress
TranscriptomicsDNMT3B7, an aberrant DNMT3B isoform, suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma
In adult cancers, epigenetic changes and aberrant splicing of the DNMT3B is commonly observed, and the pattern of gene methylation and expression has been shown to be modified by DNMT3B7, a truncated protein of DNMT3B. Much less is known about the mechanism of epigenetic changes in the pediatric ca...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36350 | biostudies-arrayexpress
TranscriptomicsTET-catalyzed 5-hydroxymethylcytosine regulates gene expression in differentiating colonocytes and colon cancer
5-hydroxymethylcytosine (5-mC) and gene expression profiling of T84 cell differentiation; 5-hmC profiling of colon cancer colonocyte fractions T84 cell differentiation was monitored as cells formed confluent monolayers in tissue culture
ORGANISM(S): Homo sapiens 
2015-12-09 | E-GEOD-69333 | biostudies-arrayexpress
Genomicsde novo DNA Methylation Balances Hematopoietic Stem Cell Self-Renewal and Differentiation
Cytosine methylation is an epigenetic mark usually associated with gene repression. Despite a requirement for de novo DNA methylation for differentiation of embryonic stem cells, its role in somatic stem cells is unknown. Using conditional ablation, we show that loss of either, or both, Dnmt3a or Dn...
ORGANISM(S): Mus musculus 
2011-09-30 | E-GEOD-27322 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling in primary Diffuse Large B cell Lymphoma (DLBCL) and normal Germinal Center B Cells
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common aggressive form of non-Hodgkin lymphoma with variable biology and clinical behavior. The current classification does not fully explain the biological and clinical heterogeneity of DLBCLs. In this study we carried out genome-wide DNA methylatio...
ORGANISM(S): Homo sapiens 
2014-01-18 | E-GEOD-54200 | biostudies-arrayexpress
GenomicsHydroxymethylation at gene regulatory regions directs stem cell commitment during erythropoiesis
CD34 positive hematopoietic stem cells were differentiated into erythroid lineage. Next generation sequencing (NGS) of 5hmC affinity pulldown and RNAseq were performed in four time point of different stages of erythroid differentiation. 4 RNA-Seq Samples (d0, d3, d7 and d10); 4 affinity-pulldown (d...
ORGANISM(S): Homo sapiens 
2014-03-28 | E-GEOD-40243 | biostudies-arrayexpress
GenomicsEpigenomic profiling of Acute myeloid leukemia subtypes from primary tumor samples
Here we used Illumina NGS for high-throughput profiling of the DNA methylome(ERRBS) and hydroxymethylome(hMe-Seal) of primary tumor samples with Acute Myeloid Leukemia(AML). The data can be used to compare hydroxymethylation and methylation patterns from different AML subtypes and normal bone marrow...
ORGANISM(S): Homo sapiens 
2014-11-20 | E-GEOD-52945 | biostudies-arrayexpress
TranscriptomicsTet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Recurrent somatic mutations in TET2 and in other genes that regulate the epigenetic state have been identified in patients with myeloid malignancies and in other cancers. However, the in vivo effects of Tet2 loss have not been delineated. We report here that Tet2 loss leads to increased stem-cell...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-27816 | biostudies-arrayexpress
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