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ProteomicsDefining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Serous tubal intraepithelial carcinomas (STIC lesions) in the human fallopian tube epithelium (hFTE) are theorized to give rise to high grade serous ovarian cancers (HGSOC). Small extracellular vesicles (sEVs) are known to mediate key signaling in both normal and cancerous tissues, but few ex vivo s...
ORGANISM(S): Homo sapiens (Human) 
2025-07-15 | PXD066017 | Pride
High grade serous ovarian cancer Extracellular vesicles Fallopian tube 
TranscriptomicsRepertoire of miRNAs in epithelial ovarian cancer determined by next generation sequencing of small RNA cDNA libraries
Background: MicroRNAs (miRNAs) are small regulatory RNAs that are implicated in cancer pathogenesis and have recently shown promise as blood-based biomarkers for cancer detection. Epithelial ovarian cancer is a deadly disease for which improved outcomes could be achieved by successful early detectio...
ORGANISM(S): Homo sapiens 
2009-03-12 | E-GEOD-15190 | biostudies-arrayexpress
UnknownInherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Not available
S-EPMC4302212 | biostudies-literature
GenomicsSpatial Transcriptomic Profiling of the Human Fallopian Tube Epithelium Reveals Region-specific Gene Expression Patterns
Spatial Transcriptomic Profiling of the Human Fallopian Tube Epithelium Reveals Region-specific Gene Expression Patterns
PRJNA1226108 | ENA
GenomicsDefining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
Defining the Ovarian Cancer Precancerous Landscape through Modeling Fallopian Tube Epithelium Reprogramming Driven by Extracellular Vesicles
PRJNA1281065 | ENA
TranscriptomicsZNF-mediated resistance to imatinib mesylate in gastrointestinal stromal tumor
siRNA knock-down of ZNF genes determined to impact gastrointestinal stromal tumor response to imatinib were used to determine functional significance of ZNFs and identify key targets related to imatinib resistance. exploratory array design to identify candidate effector genes for targeted study
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-40080 | biostudies-arrayexpress
ProteomicsCirculating extracellular vesicle protein biomarker associated with early cancer lesions for early detection of high-grade serous ovarian cancer
Small extracellular vesicles (sEVs), lipid-bilayer delimited particles (50-200 nm) released by cells, are considered a new class of liquid biopsy biomarkers for stealth cancers, e.g., HGSOC. HGSOC originates from the fallopian tube (FT) and progresses from p53 signatures to a precursor lesion called...
ORGANISM(S): Homo sapiens (Human) 
2026-01-08 | PXD067228 | Pride
Liquid biopsy biomarker Early cancer detection Extracellular vesicles Proteomics 
ProteomicsLineage specific extracellular vesicle-associated protein biomarkers for the early detection of high grade serous ovarian cancer
High grade serous ovarian carcinoma (HGSOC) accounts for ~70% of ovarian cancer cases. Non-invasive, highly specific blood-based tests for pre-symptomatic screening in women are crucial to reducing the mortality associated with this disease. Since most HGSOCs typically arise from the fallopian tubes...
ORGANISM(S): Homo sapiens (Human) 
2023-10-09 | PXD036726 | Pride
Exosomes High grade serous Extracellular vesicles Ovarian cancer Fallopian tube Early detection Biomarkers 
TranscriptomicsTranscription profiling of human gastrointestinal stromal tumour is predictive of rapid response to imatinib mesylate
Gene expression profiling using oligonucleotide microarrays performed on tumor samples obtained before and after imatinib mesylate (IM) therapy. Rapid responding (to IM) samples were compared to non-responding/stable disease samples as measured by CT scan measurements to identify a gene signature t...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-15966 | biostudies-arrayexpress
ProteomicsIdentification of small extracellular vesicle protein biomarkers of pediatric Ewing Sarcoma
Label-free 1DLC-MS analysis of cell lines and cell line derived small extracellular vesicles (sEVs) with duplicate injections. Goal to determine shared and distinct features of these tumor cells and their respective sEVs. Samples included analyzed EWS cells with different EWS-ETS fusions (EWS-FLI1 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-31 | MSV000090623 | MassIVE
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