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TranscriptomicsCrohn's disease risk variant in GPR65 alters lysosomal function
Using an siRNA screen we identify a role for GPR65 in the defense against intracellular pathogens. Epithelial cells and macrophages lacking GPR65 exhibited impaired clearance of intracellular bacteria as well as an accumulation of aberrant phagosomes and lysosomes. Transcriptional profiling revealed...
ORGANISM(S): Mus musculus 
2016-06-15 | E-GEOD-69445 | biostudies-arrayexpress
UnknownDaple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling.
Not available
S-EPMC4484057 | biostudies-literature
UnknownClinical significance and functional role of adhesion G-protein-coupled receptors in human pancreatic ductal adenocarcinoma.
Not available
S-EPMC9902480 | biostudies-literature
UnknownA novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans.
Not available
S-EPMC4096202 | biostudies-literature
UnknownCellular mechanisms underlying response and resistance to CDK4/6 inhibitors in the treatment of hormone receptor-positive breast cancer.
Not available
S-EPMC8898415 | biostudies-literature
UnknownSpectrum of parasitic infections in centrifuged urine sediments from a newly developed tertiary care centre in Central India.
Not available
S-EPMC6261132 | biostudies-literature
UnknownCD44 splice isoform switching determines breast cancer stem cell state.
Not available
S-EPMC6362815 | biostudies-literature
TranscriptomicsIdentification and characterization of miRNAome in root, stem, leaf and tuber developmental stages of potato (Solanum tuberosum L.) by high-throughput sequencing
Purpose: MicroRNAs (miRNAs) are ubiquitous components of endogenous plant transcriptome. miRNAs are small, single-stranded and ~21 nt long RNAs which regulate gene expression at the post-transcriptional level and are known to play essential roles in various aspects of plant development and growth. P...
ORGANISM(S): Solanum tuberosum 
2014-01-09 | E-GEOD-52599 | biostudies-arrayexpress
UnknownCold Stress and Nitrogen Deficiency Affected Protein Expression of Psychrotrophic Dyadobacter psychrophilus B2 and Pseudomonas jessenii MP1.
Not available
S-EPMC5348510 | biostudies-literature
TranscriptomicsA genome-wide perspective of miRNAome in response to high temperature, salinity and drought stresses in Brassica juncea (Czern) L.
Purpose: To identify high temperature, sailinity and drought-responsive miRNAs at genome wide level in B. juncea var varuna. Results: In this study four small RNA libraries viz. B. juncea control (BJC), B. juncea high temperature stressed (BJH), B. juncea salinity stressed (BJS) and B. juncea drough...
ORGANISM(S): Brassica juncea 
2014-08-20 | E-GEOD-53242 | biostudies-arrayexpress
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