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TranscriptomicsCircadian regulation of a limited set of microRNAs in Drosophila
We used a microarray platform to survey the daily levels of 78 D. melanogaster miRNAs in adult heads of wildtype control flies and the arrhythmic clock mutant cyc01. At least 2 miRNAs were identified that showed robust daily abundance changes in control flies but not the cyc01 mutant. Keywords: mi...
ORGANISM(S): Drosophila melanogaster 
2010-05-27 | E-GEOD-10005 | biostudies-arrayexpress
TranscriptomicsIntegrative Annotation of Human Large Intergenic Non-Coding RNAs Reveals Global Properties and Specific Subclasses
Large intergenic non-coding RNAs (lincRNAs) are emerging as key regulators of diverse cellular processes. Determining the function of individual lincRNAs remains a challenge. Recent advances in RNA sequencing (RNA-Seq) and computational methods allow for an unprecedented analysis of such transcripts...
ORGANISM(S): Homo sapiens 
2011-08-27 | E-GEOD-30554 | biostudies-arrayexpress
TranscriptomicsMouse CD4+/CD8+ thymocytes from miR-181a1/b1 KO vs WT
miR-181a1/b1, miR-181a2/b2, and miR-181c/d belong to a highly conserved family of microRNA clusters, yet their role in vivo is poorly understood. Here we show that the miR-181a1/b1 cluster is absolutely essential for NKT development and is a critical determinant of thymocyte proliferation, survival ...
ORGANISM(S): Mus musculus 
2014-04-09 | E-GEOD-41090 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs regulate adipogenesis (Illumina RNA-Seq)
Adipogenesis involves the regulation of hundreds of genes by several well-studied proteins, but the role of long, noncoding RNAs in this process has not been defined. We track the regulation of hundreds of lncRNAs during adipocyte differentiation, and find several that are essential for this proces...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-29898 | biostudies-arrayexpress
TranscriptomicsLong non-coding RNAs regulate adipogenesis (Affymetrix)
Adipogenesis involves the regulation of hundreds of genes by several well-studied proteins, but the role of long, noncoding RNAs in this process has not been defined. We track the regulation of hundreds of lncRNAs during adipocyte differentiation, and find several that are essential for this proces...
ORGANISM(S): Mus musculus 
2013-02-15 | E-GEOD-29897 | biostudies-arrayexpress
TranscriptomicsRNA-Seq characterization of human H1-derived NPC differentiation timecourse
High resolution transcriptional profiling of H1-derived human neuronal precursor cells over a timecourse of differentiation in vitro. Human NPC differentiation timecourse covers Days 0,1,2,4,5,11, and 18 after induction of neuronal differentiation as described in manuscript. Each time point was assa...
ORGANISM(S): Homo sapiens 
2014-04-15 | E-GEOD-56785 | biostudies-arrayexpress
TranscriptomicsDifferential Gene and Transcript Expression Analysis with TopHat and Cufflinks
This submission includes the sample data for a protocol covering differential expression analysis with TopHat and Cufflinks. The protocol also covers several accessory tools and utilities that aid in managing data, including CummeRbund, a tool for visualizing RNA-Seq analysis results. While the pro...
ORGANISM(S): Drosophila melanogaster 
2011-09-09 | E-GEOD-32038 | biostudies-arrayexpress
TranscriptomicsE14.5 mouse cortical neurospheres in response to Fezf2 over-expression
RNA Sequencing of E14.5 mouse cortical neurospheres in response to Fezf2 over-expression 2 replicates each of GFP-transfected or Fezf2/GFP-transfected E14.5 mouse cortical neurospheres. Paired-end sequencing 101bp.
ORGANISM(S): Mus musculus 
2014-07-06 | E-GEOD-56446 | biostudies-arrayexpress
TranscriptomicsTrans-chromosomal regulation by a novel lincRNA required for adipogenesis that escapes X-chromosome inactivation
Long noncoding RNAs (lncRNAs) have emerged as an important layer of genome regulation with common mechanistic themes including the formation of ribonucleoprotein complexes. Here, we present a novel X-linked lncRNA termed linc-Firre that escapes X-chromosome inactivation and forms trans-chromosomal i...
ORGANISM(S): Homo sapiens 
2013-06-01 | E-GEOD-45157 | biostudies-arrayexpress
TranscriptomicsFezf2 overexpression in murine cortical progenitors in vivo
Corticospinal motor neurons (CSMN) are one specialized class of cortical excitatory neurons, which connect layer Vb of the cortex to the spinal cord. a master transcription factor –Forebrain expressed zinc finger 2 (Fezf2) – has been identified that is necessary for the fate specification of CSMN. F...
ORGANISM(S): Mus musculus 
2014-07-06 | E-GEOD-56451 | biostudies-arrayexpress
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