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TranscriptomicsGene Expression Profiling in the Lungs of Patients with Chronic Obstructive Pulmonary Disease (COPD) and Lung Cancer
COPD is a common and disabling lung disease for which very few therapeutic options are currently available. We reasoned that global gene expression profiling of COPD lungs could reveal previously unidentified disease pathways for potential therapeutic interventions. Forty-eight human lung samples we...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8500 | biostudies-arrayexpress
ProteomicsMulti-omic Evaluation of PLK1 Inhibitor—Onvansertib—in Colorectal Cancer Spheroids
Polo-like kinase 1 (Plk1) is a serine/threonine kinase involved in regulating the cell cycle. It is activated by aurora kinase B along with the cofactors Borealin, INCE, and survivn. Plk1 is involved in the development of resistances to chemotherapeutics such as doxorubicin, taxol, and gemcitabine. ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054453 | Pride
Colorectal cancer Lipidomics Cell cycle Spheroids Proteomics Spatial lipidomics Plk-1 inhibition Mass spectrometry imaging 
ProteomicsEvaluating the Performance of the Astral Mass Analyzer for Quantitative Proteomics Using Data Independent Acquisition
We evaluate the quantitative performance of the newly released Asymmetric Track Lossless (Astral) analyzer. Using data independent acquisition, the Orbitrap Astral mass spectrometer quantifies 5 times more peptides per unit time than state-of-the-art Orbitrap mass spectrometers, which have long been...
ORGANISM(S): Homo Sapiens 
PXD042704 | panorama
ProteomicsBarley flag leaf LC-MS/MS - Proteomic comparison of near-isogenic barley (Hordeum vulgare L
Senescence is the last developmental phase of plant tissues, plant organs and, in the case of monocarpic senescence, entire plants. In monocarpic crops such as barley, it leads to massive remobilization of nitrogen (primarily from degradation of photosynthetic proteins) and other nutrients to develo...
ORGANISM(S): Hordeum vulgare (Barley) 
2017-02-08 | PXD002307 | Pride
Barley Flag leaf Senescence Lc-ms/ms 
TranscriptomicsRetinoids induce rapid dynamic changes in the non-coding RNAs and epigenetic profiles of murine Hox clusters.
Physiologically relevant concentrations of retinoic acid are added to Mouse ES cells and a time course (0-72 hours) is examined with expression tiling arrays and RNA-seq to characterize the early dynamics of expression of coding and non-coding RNAs in and around the Hox clusters. Gene expression is ...
ORGANISM(S): Mus musculus 
2015-04-27 | E-GEOD-67610 | biostudies-arrayexpress
TranscriptomicsRibosome profiling of chondrocytic cell line SW1353 following exposure to IL-1B
Osteoarthritis is a chronic disease characterised by the loss of articular cartilage in synovial joints through a process of extracellular matrix destruction that is strongly associated with inflammatory stimuli. Chondrocytes undergo changes to their protein translation capacity during osteoarthriti...
ORGANISM(S): Homo sapiens 
2019-07-12 | E-MTAB-7466 | biostudies-arrayexpress
ProteomicsUrine Large Extracellular Vesicle LC-MS/MS Data from a Chronic Kidney Disease Rat Model
This study examined large renal tubule extracellular vesicles (LRT-EVs) isolated from urine of a 5/6 nephrectomy (5/6Nx) rat model that recapitulates many elements of human chronic kidney disease (CKD). Within weeks of 5/6Nx rats spontaneously exhibit proximal tubular damage including brush boarder...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-26 | PXD019207 | Pride
Extracellular vesicles Urine Kidney Lc-ms/ms 
UnknownValidation and multi-site deployment of a lyophilized qRT-PCR reagent for the molecular diagnosis of avian influenza and rabies in Sub-Saharan African regions.
Not available
S-EPMC12345159 | biostudies-literature
TranscriptomicsInterferon lambda restricts West Nile virus neuroinvasion by enhancing integrity of the blood-brain barrier
Although type III interferons (IFN), also known as IFN-λ or IL28/IL-29, restrict infection by several viruses, their mechanism of inhibitory action has remained uncertain. We used recombinant IFN-λ and mice lacking the IFN-λ receptor (IFNLR1) to evaluate the effect of IFN-λ on infection with West Ni...
ORGANISM(S): Mus musculus 
2015-01-08 | E-GEOD-64735 | biostudies-arrayexpress
ProteomicsMatched Lung Tumor And Emphysematous Matrix Proteomics, Transcriptomics, and Translatomics
Chronic obstructive pulmonary disease (COPD) is a known risk factor for developing lung cancer suggesting that the COPD stroma contains factors supporting tumorigenesis. Since cancer initiation is complex we used a multi-omic approach to identify gene expression patterns that distinguish COPD stroma...
ORGANISM(S): Homo sapiens (Human) 
2019-05-28 | PXD007919 | Pride
Translatomics Copd Lung cancer Data integration Transcriptomics Rna Jive Proteomics Emphysema 
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