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TranscriptomicsProtective unfolded protein response in human pancreatic beta cells transplanted into mice
Islet transplantation exposes beta cells to mild hyperglycemia and to the abnormal environment of the transplant site. These conditions may affect beta cells and induce the expression of genes involved in beta cell damage. Gene expression profile of human beta cells exposed to mild hyperglycemia by ...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-22097 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of surgical liver biopsies from 13 obese (nine with type 2 diabetes) and five control subjects
Hepatic lipid accumulation is an important complication of obesity linked to risk for type 2 diabetes. To identify novel transcriptional changes in human liver which could contribute to hepatic lipid accumulation and associated insulin resistance and type 2 diabetes (DM2), we evaluated gene expressi...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-15653 | biostudies-arrayexpress
TranscriptomicsHuman skeletal muscle - type 2 diabetes and family history positive individuals - Mexican American
Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic beta-cell dysfunction. In high-risk subjects, the earliest detectable abnormality is insulin resistance in skeletal muscle. Impaired insulin-mediated signaling, gene expression, and glycogen synthesis, and accumulati...
ORGANISM(S): Homo sapiens 
2010-04-27 | E-GEOD-21340 | biostudies-arrayexpress
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