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Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
miRNA expression profiles of WI38 primary human fibroblasts with an active or inactive p53. Cells were compared under normal untreated conditions (young and proliferating cells), after DNA damage with Doxorubicin, and upon entry into replicative senescence. Keywords: miRNA, WI-38, p53, GSE56, Senes...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-12450 | biostudies-arrayexpress
Transcriptomicsp53-repressed miRNAs are Involved with E2F in a Feed Forward Loop Promoting Proliferation
Analysis of miRNA expression in human breast cancer samples with Agilent's miRNA arrays. These samples are part of a study where we have investigated the mammalian cell proliferation control network consisting of transcription regulators, E2F and p53, their targets, and a family of 14 microRNAs. We ...
ORGANISM(S): Homo sapiens 
2008-09-22 | E-GEOD-12848 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of human prostate cell lines indicates an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis
This work offers a dynamic picture of epigenetic switches in carcinogenesis and contributes to an overall understanding of coordinated regulation of gene expression in cancer. Our data indicate an H3K4me3/H3K27me3 epigenetic signature of prostate carcinogenesis.
ORGANISM(S): Homo sapiens 
2009-02-12 | E-TABM-635 | biostudies-arrayexpress
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