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MetabolomicsGolgi-IP, a tool for multimodal analysis of Golgi molecular content
The Golgi is a membrane-bound organelle that is essential for protein and lipid biosynthesis. It represents a central trafficking hub that sorts proteins and lipids to various destinations or for secretion from the cell. The Golgi has emerged as a docking platform for cellular signaling pathways inc...
2023-06-27 | MTBLS6511 | MetaboLights
MetabolomicsNPC1 regulates the distribution of phosphatidylinositol 4 kinases at Golgi and Lysosome membranes
Cholesterol and phosphoinositides (PI) are two critically important lipids that are found in cellular membranes and dysregulated in many disorders. Therefore, uncovering molecular pathways connecting these essential lipids may offer new therapeutic insights. We report that loss of function of lysoso...
2021-09-15 | MTBLS2612 | MetaboLights
MetabolomicsInositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites
Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of membrane tethers to contact sites between the endoplasmic reticulum (ER) and the plasma membrane is often triggered by calcium. In contrast, we reveal here a funct...
2021-05-06 | MTBLS2444 | MetaboLights
ProteomicsTrans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
A key feature in intestinal immunity is the dynamic intestinal barrier, which separates the host from resident and pathogenic microbiota through a mucus gel impregnated with antimicrobial peptides. The mechanisms underlying the maintenance and function of this intestinal barrier are not completely ...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2022-12-12 | MSV000090883 | MassIVE
ProteomicsRegulation of the Golgi apparatus by p38 and JNK kinases during cellular stress responses
p38 and JNK are activated in response to acute stress and inflammatory signals. Through modification of a plethora of substrates, these kinases profoundly re-shape cellular physiology for the optimal response to a harmful environment and/or an inflammatory state. Here, we utilized phospho-proteomics...
ORGANISM(S): Homo sapiens (Human) 
2021-09-13 | PXD028151 | Pride
P38 Jnk Golgi 
ProteomicsPirB-CTF LC-MS/MS in hippocampus
Our result indicated PirB could undergo proteolytic process, generating a C-terminal fragment (PirB-CTF). We found PirB-CTF can translocates to the Golgi apparatus, disrupting Golgi-dependent protein transport. To investigate the novel binding partners which mediated the effect of PirB-CTF, we used ...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-08 | PXD063306 | Pride
Mouse Pirb Hippocampus Golgi apparatus C-terminal fragment 
GenomicsSalinomycin induces expression of ER and Golgi apparatus related genes in EMT cell model
Salinomycin induces expression of ER and Golgi apparatus related genes in EMT cell model
PRJNA514730 | ENA
ProteomicsTMT-based proteomic analysis of Atg5-/- mouse brain
The brains of neonatal mice (Atg5+/+ in triplicate, Atg5-/- in quadruplicate, and Atg5-/-;NSE-Atg5 in triplicate) were lysed in 500 µL of 6 M guanidine-HCl containing 100 mM Tris-HCl, pH8.0, and 2 mM DTT. The lysates were dissolved by heating and sonication, followed by centrifugation at 20,000 g fo...
ORGANISM(S): Mus Musculus (mouse) 
2024-06-01 | PXD049220 | JPOST Repository
ProteomicsMaize and Arabidopsis Golgi proteome
Comparative proteomics of ER-Golgi membranes from etiolated coleoptiles of maize (Zea mays) and young leaves of Arabidopsis (Arabidopsis thaliana) isolated by flotation centrifugation demonstrate differences in the complement of synthases and glycosyl transferases unique to the type of wall made. Ad...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Zea mays (Maize) 
2019-04-11 | PXD007612 | Pride
Flotation centrifugation Lc-msms Golgi Triple tof Arabidopsis Maize Ffe Free-flow electrophoresis 
ProteomicsA proximity labelling derived luminal proteome of the Trypanosoma brucei endoplasmic reticulum, Golgi apparatus and nuclear membrane
We employed proximity labelling to derive a proteome of the luminal content of the Trypanosoma brucei endoplasmic reticulum (ER) and Golgi apparatus. We exploited the abundant ER chaperone BiP (Binding-immunoglobulin protein) as ER BioID bait and compare to a truncated version of BiP (termed BiPN) d...
ORGANISM(S): Trypanosoma brucei 
2026-04-05 | PXD075517 | Pride
Nuclear envelope Secretory pathway Endoplasmic reticulum Golgi apparatus Trypanosoma brucei 
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