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UnknownPharmacokinetics and Pharmacodynamics of KT-474, a Novel Selective Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) Degrader, in Healthy Adults.
Not available
S-EPMC11889407 | biostudies-literature
ProteomicsKT-253, A Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors
KT-253 is a potent and selective heterobifunctional MDM2 degrader with superior activity to MDM2/p53 small molecule inhibitors. RS4;11 cells treated with KT-253 indicated no off-target protein degradation. All significantly upregulated proteins are p53 and its target genes. KT-253 overcomes p53/MDM...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD057859 | Pride
All cell line lc-msms 
UnknownImpact of Age and Comorbid Conditions on Incidence Rates of COVID-19-Associated Hospitalizations, 2020-2021.
Not available
S-EPMC11569932 | biostudies-literature
UnknownIRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial.
Not available
S-EPMC10719089 | biostudies-literature
UnknownEncorafenib Plus Cetuximab as a New Standard of Care for Previously Treated BRAF V600E-Mutant Metastatic Colorectal Cancer: Updated Survival Results and Subgroup Analyses from the BEACON Study.
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S-EPMC8078423 | biostudies-literature
UnknownManagement of adverse events from the treatment of encorafenib plus cetuximab for patients with BRAF V600E-mutant metastatic colorectal cancer: insights from the BEACON CRC study.
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S-EPMC8666642 | biostudies-literature
UnknownHealthcare-associated Respiratory Syncytial Virus in Children's Hospitals.
Not available
S-EPMC10231385 | biostudies-literature
UnknownKT-253, a Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy than MDM2 Small-Molecule Inhibitors.
Not available
S-EPMC11962396 | biostudies-literature
UnknownBinimetinib, Encorafenib, and Cetuximab Triplet Therapy for Patients With BRAF V600E-Mutant Metastatic Colorectal Cancer: Safety Lead-In Results From the Phase III BEACON Colorectal Cancer Study.
Not available
S-EPMC7370699 | biostudies-literature
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