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TranscriptomicsNon-genotoxic Hepatocarcinogens
There is no accurate and well-validated short-term test for non-genotoxic carcinogens, necessitating an expensive two year rodent bioassay before a risk assessment can begin. We have developed a short-term in vivo rat assay that predicts whether non-genotoxic chemicals are likely to induce hepatic t...
ORGANISM(S): Rattus norvegicus 
2007-06-22 | E-GEOD-8251 | biostudies-arrayexpress
TranscriptomicsAnalysis of the impact of cellular miRNA signatures on the profiles of circulating miRNA biomarkers (variability data)
Circulating miRNAs are an emerging class of biomarkers correlating their specific expression patterns to disease states. A considerable proportion of hematopoietically-derived miRNAs are present in plasma with the ability to confound the signature of true circulating miRNA species. We use microarray...
ORGANISM(S): Homo sapiens 
2011-06-17 | E-GEOD-27253 | biostudies-arrayexpress
TranscriptomicsAnalysis of the impact of cellular miRNA signatures on the profiles of circulating miRNA biomarkers (fractionation data)
Circulating miRNAs are an emerging class of biomarkers correlating their specific expression patterns to disease states. A considerable proportion of hematopoietically-derived miRNAs are present in plasma with the ability to confound the signature of true circulating miRNA species. We use microarray...
ORGANISM(S): Homo sapiens 
2011-06-17 | E-GEOD-27230 | biostudies-arrayexpress
TranscriptomicsLiver Pharmacology and Xenobiotic Response Repertoire
A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a ...
ORGANISM(S): Rattus norvegicus 
2008-03-28 | E-GEOD-8858 | biostudies-arrayexpress
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