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TranscriptomicsTranscriptomic analysis of the estrogenic effect of soy protein isolate in rat uterus
There are concerns regarding possible reproductive toxicity from consumption of soy including an increased risk of endometriosis and endometrial cancer. We used global uterine gene expression profiles in adult ovariectomized (OVX) female rats assessed by RNAseq to examine the estrogenicity of soy pr...
ORGANISM(S): Rattus norvegicus 
2015-06-13 | E-GEOD-69819 | biostudies-arrayexpress
TranscriptomicsEarly growth response protein-1 coordinates lipotoxicity-associated placental inflammation: Role in Maternal Obesity
Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA, 500 uM) and/or TNF-alpha (10 ng/ml) treatment for 24 h. Microarray analysis revealed that placental cytotrophoblasts increas...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-43685 | biostudies-arrayexpress
TranscriptomicsFemale Mice Lacking p47phox Have Altered Adipose Tissue Gene Expression and are Protected against High Fat-Induced Obesity and Metabolic Syndrome
Oxidative stress in adipose tissue and liver has been linked to the development of obesity. NADPH oxidases (NOX) enzymes are a major source of reactive oxygen species (ROS). The current study was designed to determine if NOX2-generated ROS play a role in development of obesity and metabolic syndrom...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-41932 | biostudies-arrayexpress
TranscriptomicsEffect of Concentration and type of Dietary Fatty Acid on Development of Nonalcoholic Fatty Liver Disease
The current study was designed to determine if dietary fatty acid concentration and composition affects the development and progression of nonalcoholic fatty liver disease. Male SD rats were overfed diets low (5%) or high (70%) fat diets via total enteral nutrition where the fat source was olive oil...
ORGANISM(S): Rattus norvegicus 
2011-10-23 | E-GEOD-33166 | biostudies-arrayexpress
TranscriptomicsChanges in mammary gene expression and morphology following consumption of soy protein isolate in female Sprague-Dawley rats differs from that produced by 17b-estradiol treatment
Soy foods have been suggested to have both positive health benefits and potentially adverse effects largely as a result of their content of isoflavone phytoestrogens. Since soy protein isolate (SPI) contains isoflavones, in addition to purported health benefits, safety concerns have been raised rega...
ORGANISM(S): Rattus norvegicus 
2012-05-21 | E-GEOD-38060 | biostudies-arrayexpress
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