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GenomicsFgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of Trophoblast Stem Cells
Derivation and maintenance of TS cells depends on the presence of Fgf signalling. Numerous gene knock-out experiments identified the mitogen activated kinase Mek/Erk branch of the Fgf signalling pathway as predominantly active in both TS cells and extraembryonic ectoderm. Therefore, we tested change...
ORGANISM(S): Mus musculus 
2015-08-18 | E-MTAB-3565 | biostudies-arrayexpress
TranscriptomicsCompensatory cis-trans regulation of mouse liver gene expression
Two inbred mouse strains, C57BL/6J and CAST/EiJ, were crossed to generate both initial and reciprocal F1 crosses. For each genetically distinct class of mice (F0 C57BL/6J, F0 CAST/EiJ, F1i - C57BL/6J x CAST/EiJ, F1r - CAST/EiJ x C57BL/6J, where the male parent is listed first), samples were collecte...
ORGANISM(S): Mus musculus 
2012-09-07 | E-MTAB-1091 | biostudies-arrayexpress
TranscriptomicsRNA-seq of paired oocytes and granulosa cells from 3M and 12M old mice after natural and superovulation
Oocytes and granulosa cells were collected after natural and superovulation in young (3 month-old) and old (12 month-old) mice while conserving pairing information between oocyte and granulosa cells from each cumulus-oocyte-complex (COC). This experimental design allows for the analysis of the effec...
ORGANISM(S): Mus musculus 
2024-09-22 | E-MTAB-13479 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA (10X Chromium) of naked mole rate DMBA/TPA treated or control back skin and matched livers (CRUK A) 2022
We generated single cell transcriptomes from full thickness skin biopsies in naked mole-rat to quantify the skin cell types found in this species (control samples). To study if and how naked mole-rat skin changes upon exposure to a carcinogen, we performed a classical two-stage skin carcinogenesis e...
ORGANISM(S): Heterocephalus glaber 
2023-11-21 | E-MTAB-12451 | biostudies-arrayexpress
Transcriptomics10X Chromium Single-cell RNA sequencing of the female reproductive tract during aging in C57BL/6 mice
The aim of the study was to assess the cellular composition and transcriptional changes at single-cell resolution of the female reproductive tract during ageing in ovary, oviduct and uterus. Tissues of aged mice were collected at the age of 9,12 and 15 months. All tissues were collected and digested...
ORGANISM(S): Mus musculus 
2024-01-31 | E-MTAB-12889 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of six mammals
Homologous vertebrate tissues express a highly conserved set of transcribed genes; paradoxically, expression of tRNAs that are required to translate mRNAs into proteins have been reported to be divergent. To resolve this paradox, we mapped the genome-wide occupancy of pol III in primary tissues iso...
ORGANISM(S): Mus musculus 
2011-07-29 | E-MTAB-424 | biostudies-arrayexpress
TranscriptomicsSpatial transcriptomics of 3-month-old and 18-month-old mouse ovarian and uterine tissues
We used Visium technology (10X Genomics) to infer cell-to-cell communication in ovarian and uterine tissue based on spatial proximity. Organs from 3-month mice in diestrus and 18-month old mice were collected and frozen in OCT. 10 µm thick tissue slices were placed on Visium Spatial Gene Expression ...
ORGANISM(S): Mus musculus 
2024-07-23 | E-MTAB-12105 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA (10X Chromium) of mouse DMBA/TPA treated or control back skin and matched livers (2) (IKMB) 2022
We generated single cell transcriptomes from full thickness skin biopsies in mouse to quantify the skin cell types found in this species (control samples). To study how mouse skin changes upon exposure to a carcinogen, we performed a classical two-stage skin carcinogenesis experiment, wherein cancer...
ORGANISM(S): Mus musculus 
2023-11-21 | E-MTAB-12456 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA (10X Chromium) of mouse DMBA/TPA treated or control back skin and matched livers (1) (DKFZ) 2022
We generated single cell transcriptomes from full thickness skin biopsies in mouse to quantify the skin cell types found in this species (control samples). To study how mouse skin changes upon exposure to a carcinogen, we performed a classical two-stage skin carcinogenesis experiment, wherein cancer...
ORGANISM(S): Mus musculus 
2023-11-21 | E-MTAB-12454 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA (10X Chromium) of naked mole rate DMBA/TPA treated or control back skin and matched livers (CRUK B) 2022
We generated single cell transcriptomes from full thickness skin biopsies in naked mole-rat to quantify the skin cell types found in this species (control samples). To study if and how naked mole-rat skin changes upon exposure to a carcinogen, we performed a classical two-stage skin carcinogenesis e...
ORGANISM(S): Heterocephalus glaber 
2023-11-21 | E-MTAB-12461 | biostudies-arrayexpress
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