Bariatric surgery improves hyperglycemia in obesity and type 2 diabetes (T2D), yet its central mechanisms remain unclear. Through cerebrospinal fluid proteomic profiling of rats, we identify reduced central malate dehydrogenase 2 (MDH2) levels that correlate with surgery-induced restoration of normo...
We performed stable isotope labeling of amino acids in cell culture (SILAC) and mass spectrometry (MS) analysis to identify potential acetylation sites on METTL3 in response to ectopic p300 expression.
