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TranscriptomicsThreshold of Biologic Response of the Small Airway Epithelium to Low Levels of Tobacco Smoke
Background: Healthy individuals exposed to low levels of cigarette smoke have a decrement in lung function and higher risk for lung disease compared to unexposed individuals. We hypothesized that healthy individuals exposed to low levels of tobacco smoke must have biologic changes in the small airwa...
ORGANISM(S): Homo sapiens 
2011-02-02 | E-GEOD-19667 | biostudies-arrayexpress
TranscriptomicsEffect of cigarette smoke on gene expression in mammary epithelial cells [methylation]
Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increases the risk of breast cancer. Little is known, however, about the molecular mechanisms by which tobacco smoke contributes to breast carcinogenesis. To investigate these mechanisms we have ana...
ORGANISM(S): Homo sapiens 
2013-08-12 | E-GEOD-42623 | biostudies-arrayexpress
TranscriptomicsEffect of cigarette smoke on gene expression in mammary epithelial cells [gene expression]
Recent epidemiological studies demonstrate that both active and involuntary exposure to tobacco smoke increases the risk of breast cancer. Little is known, however, about the molecular mechanisms by which tobacco smoke contributes to breast carcinogenesis. To investigate these mechanisms we have ana...
ORGANISM(S): Homo sapiens 
2013-08-12 | E-GEOD-42667 | biostudies-arrayexpress
TranscriptomicsNilotinib (Tasigna) in the Treatment of Early Diffuse Systemic Sclerosis: An Open-Label, Pilot Clinical Trial
To assess the safety, efficacy, and molecular change associated with treatment of patients with early, diffuse cutaneous systemic sclerosis (dcSSc) with nilotinib (Tasigna™). In this open-label pilot trial 6 adult patients with early dcSSc received nilotinib. Primary endpoints were safety and change...
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-65405 | biostudies-arrayexpress
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