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TranscriptomicsNeonatal DNA methylation profile in humans is specified by a complex interplay between intrauterine environmental/ genetic factors subject to tissue-specific influence
Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an estimation of the relative contribution of genetic, shared and non-shared environmental factors to phenotypic variability. Using DNA methylation profiling of ~20,000 CpG sites as a phenotype, we have examined discordan...
ORGANISM(S): Homo sapiens 
2012-07-17 | E-GEOD-36642 | biostudies-arrayexpress
TranscriptomicsWide ranging DNA methylation differences of primary trophoblast cell populations and derived-cell lines
Difficulties associated with long term culture of primary trophoblasts have proven to be a major hurdle in their functional characterization. In order to circumvent this issue, several model cell lines have been established over many years using a variety of different approaches. Due to their differ...
ORGANISM(S): Homo sapiens 
2011-01-20 | E-GEOD-26683 | biostudies-arrayexpress
TranscriptomicsExpression data from postnatal mouse brain regions of Ts1Cje and disomic C57BL/6 mice.
The Ts1Cje mouse model of Down syndrome (DS) has partial triplication of mouse chromosome 16 (MMU16), which is partially homologous to human chromosome 21. The mouse model develops various neuropathological features identified in DS individuals. We analysed the effect of partial triplication of the ...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-49050 | biostudies-arrayexpress
TranscriptomicsEWS/WT1 co-operates with the loss of p53 to exert its oncogenic effects and up-regulates canonical Wnt pathway signaling.
The t(11;22)(p13;q12) translocation is pathognomonic for the highly aggressive desmoplastic small round cell tumour (DSRCT). The translocation fuses exon 7 of the EWS gene to exon 8 of the WT1 gene (EWS/WT1). Two splice variants of EWS/WT1 exist, arising from the presence (+KTS) or absence (-KTS) of...
ORGANISM(S): Mus musculus 
2014-11-01 | E-GEOD-42649 | biostudies-arrayexpress
TranscriptomicsEvidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors.
Background: the human placenta facilitates the exchange of nutrients, gas and waste between the fetal and maternal circulations. It also protects the fetus from the maternal immune response. Due to its role at the feto-maternal interface, the placenta is subject to many environmental exposures that ...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31781 | biostudies-arrayexpress
TranscriptomicsProfiling of spatio-temporally regulated transcripts during cerebral corticogenesis in the mouse
The cerebral cortex plays an important role in cognitive function and specialized perception in mammals and its development requires highly specific spatio-temporal control of gene expression. The study identified stage- and region-specific markers throughout cerebral corticogenesis at various impor...
ORGANISM(S): Mus musculus 
2009-09-25 | E-GEOD-15031 | biostudies-arrayexpress
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