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TranscriptomicsThe stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Transcriptional profiling of control and MKK7-deficient primary mouse pneumocytes after oncogenic KRasG12 induction Two-condition experiment, MKK7 proficient vs. MKK7 deficient pneumocytes. 3 Biological replicates: 3 control, 3 knock out, independently grown and harvested. 3 technical replicates p...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26763 | biostudies-arrayexpress
ProteomicsVersican regulates Collagen fibrillation and Tenascin-C expression, suppressing podosome formation and pulmonary fibrosis
The activation and accumulation of lung fibroblasts, leading to aberrant deposition of extracellular matrix (ECM) components, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis (IPF), a lethal and currently incurable disease. ECM deposition perpetuates fibroblast activation and stimulates ECM...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD060583 | Pride
Pulmonary fibrosis  extracellular matrix (ecm)  lung fibroblasts  podosomes  ecm invasion  versican (vcan)  hyaluronan (ha)  collagen (col)  tenascin-c (tnc) 
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