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TranscriptomicsNEUROMESO
Exposure of mouse ESCs to a sequence of extrinsic signals, which recapitulates in vivo development, generates a bipotential neuromesodermal precursor (NMP) that can be directed to differentiate into either spinal cord or paraxial mesodermal tissue. To induce differentiation,mouse ES cells were plate...
ORGANISM(S): Mus musculus 
2014-07-18 | E-MTAB-2268 | biostudies-arrayexpress
TranscriptomicsATAC-seq on ESCs undergoing directed differentiation towards defined neural fates
We have used ATAC-seq to track cell state changes that occur during the differentiation of mouse embryonic stem cells to defined neural progenitor fates. We have performed ATAC-seq every 24 hours in cells en route to 3 distinct neural progenitors fates, anterior, hindbrain and spinal cord. This has ...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6337 | biostudies-arrayexpress
GenomicsSox2 ChIP-seq in hindbrain and spinal cord neural progenitors differentiated from mouse embryonic stem cells
Sox2 is a key determinant of neural cell identity, expressed in neural progenitors from anterior to posterior levels. We asked if the occupancy of this factor changes in neural progenitors with different axial identities. To this end, we performed the directed differentiation of mouse embryonic stem...
ORGANISM(S): Mus musculus 
2018-08-27 | E-MTAB-6348 | biostudies-arrayexpress
TranscriptomicsRetinoic acid mediated neural and mesoderm specification during vertebrate trunk development
Neuromesodermal progenitors are located in the caudal lateral epiblast region of embryos and are important for the generation of spinal cord and somite tissue that forms the vertebrate body. In this study we use single cell transcriptomics to define the molecular signature of in vivo and in vitro NM...
ORGANISM(S): Mus musculus 
2017-03-22 | E-MTAB-5208 | biostudies-arrayexpress
TranscriptomicsAldh1b1 controlled timing of pancreas specification is important for β cell functionality and glucose homeostasis in the adult.
Maintenance of normal glucose homeostasis is disturbed in diabetes. In the β cell, this involves a glucose sensor converting increased glucose levels to insulin secretion. Understanding the developmental regulatory networks that define a fully functional β cell is important for elucidating the genet...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-58025 | biostudies-arrayexpress
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