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ProteomicsMETTL21C methylates Alanine tRNA synthetase at lysine 943 in muscle tissue
Protein lysine methylation is a common post-translational modification (PTM) detected throughout the human proteome that plays important roles in diverse biological processes. In the human genome, there are greater than one hundred known and candidate protein lysine methyltransferases (PKMTs), many ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-02 | PXD019886 | Pride
Human Methylation Aars1 Lc-ms/ms 
TranscriptomicsING4 ChIP-chip in HT1080 cells
Aberrations in chromatin dynamics play a fundamental role in tumorigenesis, yet relatively little is known of the molecular mechanisms linking histone lysine methylation to neoplastic disease. ING4 (Inhibitor of Growth 4) is a native subunit of an HBO1 histone acetyltransferase (HAT) complex and a t...
ORGANISM(S): Homo sapiens 
2010-05-17 | E-GEOD-13412 | biostudies-arrayexpress
ProteomicsSETMAR methyl-lysine (3xMBT) pull-down
SILAC labeled HT-1080 cell lysate (K0R0 and K8R10) were treated with active or catalytic inactive SETMAR methyltransferase enzyme. Samples were combined and proteins modified by methyl-lysine enriched by 3xMBT. Quantitative comparison identified candidate proteins with increase methylation following...
ORGANISM(S): Homo sapiens (Human) 
2016-06-24 | PXD001635 | Pride
Methylation Setmar 
TranscriptomicsJade1 ChIP-chip on ENCODE Tiling array
Several MYST-family histone acetyltransferase (HAT) enzymes associate with specific ING tumor suppressor proteins. ING complexes containing the HBO1 HAT protein are the major source of histone H4 acetylation in vivo and have been shown to play critical roles in gene regulation and DNA replication. H...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-14309 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [Transduction]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Mus musculus 
2011-11-29 | E-GEOD-29150 | biostudies-arrayexpress
TranscriptomicsNuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage [expression]
ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 sele...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-47645 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [RNAi]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29147 | biostudies-arrayexpress
TranscriptomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [TKO]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29148 | biostudies-arrayexpress
GenomicsNSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming [ChIP]
NSD2 (also named MMSET and WHSC1) is a histone lysine methyltransferase that is implicated in diverse diseases and commonly overexpressed in multiple myeloma due to a recurrent t(4;14) chromosomal translocation. However, the precise catalytic activity of NSD2 is obscure, preventing progress in unde...
ORGANISM(S): Homo sapiens 
2011-11-29 | E-GEOD-29146 | biostudies-arrayexpress
TranscriptomicsNuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage [ChIP-chip]
ING2 (inhibitor of growth family member 2) is a component of a chromatin-regulatory complex that represses gene expression and is implicated in cellular processes that promote tumor suppression. However, few direct genomic targets of ING2 have been identified and the mechanism(s) by which ING2 sele...
ORGANISM(S): Homo sapiens 
2013-12-31 | E-GEOD-47688 | biostudies-arrayexpress
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