Gpcr - OmicsDI

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Unknown (4375)
Transcriptomics (1812)
Genomics (345)
Proteomics (143)
Other (18)
Models (17)
Metabolomics (3)
Methylation profiling (1)

Organisms

Homo sapiens (615)
Mus musculus (413)
Arabidopsis thaliana (86)
Rattus norvegicus (68)
Drosophila melanogaster (42)
Saccharomyces cerevisiae (40)
Sus scrofa (26)
Danio rerio (24)
Caenorhabditis elegans (15)
Bos taurus (14)
synthetic construct (13)
Zea mays (12)
Oryza sativa (12)
Dictyostelium discoideum (12)
Solanum tuberosum (11)
Staphylococcus aureus (10)
Escherichia coli (10)
Corynebacterium glutamicum ATCC 13032 (9)
Plasmodium falciparum (8)
Eisenia fetida (7)
Xenopus laevis (7)
Ferroglobus placidus DSM 10642 (6)
Pimephales promelas (6)
Macaca mulatta (6)
Streptomyces coelicolor (6)
Candida albicans (6)
Schizosaccharomyces pombe (5)
Phaeodactylum tricornutum (5)
Enterococcus faecium (5)
cellular organisms (2)

Organisms

Mus musculus (105)
Homo sapiens (100)
Rattus norvegicus (11)
Caenorhabditis elegans (10)
Drosophila melanogaster (4)
Sus scrofa (3)
Bos taurus (2)
Anguilla anguilla (1)
Lasius niger (1)
Spongilla lacustris (1)
Acropora millepora (1)
Entamoeba histolytica (1)
Ixodes ricinus (1)
Dictyostelium discoideum (1)
Oreochromis niloticus (1)
Mesocricetus auratus (1)
Danio rerio (1)
Citrobacter portucalensis (1)
Trichoderma reesei (1)
Saccharomyces cerevisiae (1)
Arabidopsis thaliana (1)

Repository

biostudies-arrayexpress (1637)
ENA (299)
geo (245)
pride (89)
MassIVE (25)
BioModels (14)
iProX (13)
EGA (9)
jPOST (5)
PanoramaPublic (5)
MetaboLights (3)
PMR (3)
GPMDB (1)

Tissue

Cell culture (21)
Epithelial cell (9)
Fibroblast (5)
Permanent cell line cell (4)
Monocyte (4)
Macrophage (3)
Heart (3)
Brain (3)
Dendritic cell (3)
Kidney (3)
Sperm (2)
Embryonic stem cell (2)
Early embryonic cell (2)
Bone marrow (2)
Testis (2)
T cell (2)
Dermis microvascular lymphatic vessel endothelial cell (1)
Uvea (1)
Uveal melanoma cell (1)
Smooth muscle cell (1)
Osteoclast (1)
HEK-293 cell (1)
Malignant cell (1)
HEK-293T cell (1)
Electrically active cell (1)
Keratinocyte (1)
Melanocyte (1)
Bile (1)
Adipose tissue (1)
Shoot (1)

Disease

Normal (13)
Breast adenocarcinoma (2)
Malignant Neoplasm (2)
Reference (2)
Prostate cancer (2)
Adenocaricinoma (1)
Benign tumor (1)
VAT - Ventilated associated tracheobronchitis (1)
Ischaemia reperfusion injury (1)
No lesions (1)
Challenged with Pieris rapae larvae (1)
HIV (1)
Major depression (1)
Carotid artery stenosis (1)
Acute type ATLL (1)
Xenografts with H1299 cell line (1)
Abdominal aortic aneurysm (1)
Acute lymphoblastic leukemia (1)
Adrenocortical Adenoma (1)
Metarhizium anisopliae infected (1)
Neurologically healthy control (1)
Bordetella pertussis inoculated (1)
Nevus (1)
Viral myocarditis (1)
Megakaryoblastic leukemia (1)
Chronic myelogenous leukemia (1)
Cancer (1)
Melanoma (1)
Nasopharyngeal carcinoma (1)
Chronic active EB virus infection (1)

Technology Type

Mass Spectrometry (89)
Shotgun proteomics (44)
Affinity purification coupled with mass spectrometry proteomics (13)
Bottom-up proteomics (11)
MSE (7)
Data-dependent acquisition (7)
HDMSE (5)
Data-independent acquisition (5)
Gel-based experiment (5)
Chemical cross-linking coupled with mass spectrometry proteomics (5)
Top-down proteomics (3)
Mass spectrometry assay (2)
SWATH MS (2)
Illumina HiSeq 2000, ILLUMINA (1)
Mass spectrometry (1)
Affinity proteomics (1)
All-ion fragmentation (1)
DiaPASEF (1)
SRM/MRM (1)

Instrument Platform

DNA Microarray Scanner BA [Agilent Technologies] (15)
Agilent G2565AA and G2565BA Microarray Scanner (9)
G2565BA DNA microarray scanner [Agilent] (9)
Illumina HiSeq 2500 (8)
Illumina NovaSeq 6000 (8)
NextSeq 500 (8)
ScanArray 4000 [PerkinElmer] (7)
GenePix 4000B [Axon Instruments] (7)
Illumina HiSeq 2000 (7)
N/A (6)
Illumina HiSeq 4000 (6)
Chromium Next GEM Single Cell Multiome ATAC + Gene Expression Reagent Bundle, (4)
Genepix (4)
ScanArray scanning hardware (4)
10X Genomics reagent kit (3)
Scanning hardware (3)
NextSeq 550 (3)
10X Chromium Nuclei Isolation Kit (2)
Illumina HiScan (2)
418 [Affymetrix] (2)
G2505B DNA microarray scanner (2)
Chromium Next GEM Single Cell Multiome Reagent Bundle (1)
10X Genomics reagents (1)
10X Chromium On-Chip Multiplex (1)
Agilent 2100 bioanalyzer (1)
NanoDrop ND-1000 (1)
TruSeq HT paired end kit (1)
FACSAria (BD) (1)
SureScan Dx (1)
PacBio RS II (1)

Publication Date

2010 (329)
2013 (207)
2012 (192)
2011 (168)
2015 (153)
2014 (141)
2008 (140)
2009 (83)
2016 (72)
2026 (69)
2025 (63)
2023 (55)
2024 (52)
2007 (45)
2021 (42)
2020 (41)
2022 (37)
2018 (31)
2017 (27)
2019 (24)
2005 (21)
2006 (19)
2004 (16)

UNIPROT ID/AC

Q8CA95 (2)
P62137 (2)
Q9ERT9 (2)
P49615 (2)
Q6P1F6 (2)
P63330 (2)
Q60829 (2)
P63328 (2)
P48453 (2)
Q63810 (2)
Q63811 (2)
P48455 (2)
Q9DBC7 (2)
P12849 (2)
P68181 (2)
Q01063 (2)
P62204 (2)
P84309 (2)
P63213 (2)
P62874 (2)
B2RSH2 (2)
P05132 (2)
Q76MZ3 (2)
P01149 (2)
P0CI39 (2)
Q8CGK7 (2)
P18851 (2)
P18852 (2)
P61168 (1)
Q60613 (1)

CHEBI ID

CHEBI:15996 (7)
CHEBI:17552 (7)
CHEBI:18367 (3)
CHEBI:18243 (2)
CHEBI:17489 (2)
CHEBI:29108 (2)
CHEBI:16027 (2)
CHEBI:15422 (2)
CHEBI:35224 (1)
CHEBI:83417 (1)
CHEBI:17962 (1)
CHEBI:15355 (1)
CHEBI:16335 (1)

Metabolite Name

Alpha-L-arabinofuranose (1)
(1'x,2S)-2-(1,2-Dihydroxy-1-methylethyl)-2,3-dihydro-7H-furo[3,2-g][1]benzopyran-7-one 2'-glucoside (1)
Serine thiol (1)
MJDBISSN00000004 (1)
Gamma-Carboxyglutamic acid (1)
M-Chlorobenzoic acid (1)
Trimethylenediaminetetraacetic acid (1)
N-Acetyl-DL-Aspartic Acid (1)
Ketomethylvaleric acid (1)
(E)-2-Decylpent-2-Enedioic Acid (1)
Pyrrolodiazepine (1)
Xi-2-Ethylheptanoic acid (1)
12-Oxopimara-9(11),15-Dien-18-Oic Acid (1)
3-Phenoxybenzoic Acid (1)
HMDB0304547 (1)
GPEtn(22:6/18:0) (1)
Delta-Tetradecalactone (1)
Trans-Dec-2-enoic acid (1)
3-[(4-chlorobenzoyl)amino]propanoic Acid (1)
Indole-3-glycol aldehyde (1)
Penigequinolone B (1)
(Z)-Cinnamaldehyde (1)
PC(P-20:0/18:4) (1)
GPCho(18:1/22:6) (1)
GPCho(18:2/16:1) (1)
GPCho(16:0/18:1) (1)
MJDBISSP00000004 (1)
Kaempferol-3,7-O-bis-Alpha-L-Rhamnoside (1)
P-Mentha-2,4(8)-dien-9,3-olide (1)
Val-gly (1)

First Public Date

2025 (54)
2026 (53)
2023 (35)
2024 (32)
2014 (24)
2020 (23)
2022 (19)
2021 (18)
2019 (12)
2018 (9)
2017 (9)
2015 (6)
2016 (3)
2013 (2)

Modelling Approach

Ordinary differential equation model (8)
Mathematical model (2)
Protein-protein interaction network (1)

Lab affiliation

School of Pharmacy, Sungkyunkwan University, South Korea (5)
NovAliX, Department of Biophysics, 16 Rue d’Ankara, 67000, Strasbourg, France; orcid.org/0000-0001-6229-4524 (3)
The Centre for Translational Pharmacology, Institute of Molecular, Cellular and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom (2)
University of Montpellier, Institut de Génomique Fonctionnelle, France (2)
University of California San Francisco (2)
Proteomics and Metabolomics Facility, MRC London Institute of Medical Sciences, Hammersmith Hospital Campus, Du Cane Rd, London W12 0NN (1)
Department of Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland (1)
Chemical Physiology and Biochemistry Oregon Health and Science University Portland, OR 97239 USA (1)
Grupo de Investigación en Neurodegeneración y Vesículas Extracelulares Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL) Hospital General Universitario Dr. Balmis Centro de Diagnóstico 6ª Planta (Edf. Gris) Avda. Pintor Baeza, 12 - 03010 Alicante (1)
Department of Molecular and Cellular Biology (MOCEL), University of Geneva, (Previously) Department of Fundamental Microbiology (DMF), University of Lausanne (1)
Laboratory of Molecular Signaling, National Institute on Alcohol Abuse and Alcoholism, NIH (1)
Advanced Clinical Biosystems Research Institute, Department of Medicine and The Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States (1)
Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia (1)
Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, Utrecht 3584 CH, The Netherlands (1)
Biozentrum, University of basel, CH (1)
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109 (1)
Department of Chemical Physiology and Biochemistry Oregon Health & Science University 3181 SW Sam Jackson Park Road, Mail Code L-334, Portland, OR, 97239, USA (1)
University of Michigan Medical School, Department of Biological Chemistry, Ann Arbor, MI (1)
Biomedical Sciences, University of Bristol (1)
Rudolf-Schoenheimer Institute of Biochemistry, Division of General Biochemistry, Medical Faculty, Leipzig University, Johannisallee 30, 04103 Leipzig, Germany (1)
Department of Pharmaceutical Chemistry & Bioanalytics Institute of Pharmacy Martin-Luther University Halle-Wittenberg Germany (1)
Assistant Professor of Neurosurgery Department of Neurosurgery Houston Methodist Research Institute Weill Cornell Medical College (1)
Proteomics Resource Center, The Rockefeller University, New York, 10065, NY, USA (1)
Marseille Proteomic, CRCM, Centre de Recherche en Cancérologie de Marseille, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105,Institut Paoli Calmettes 27 Boulevard Leï Roure CS30059 13273 Marseille Cedex 09 France (1)
Department of Cell Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, China. (1)
Pharmacology Department, Biomedical Science Institute, University of Sao Paulo, Sao Paulo, Brazil (1)
Joseph C. Wu, MD, PhD Director, Stanford Cardiovascular Institute Simon H. Stertzer, MD, Professor of Cardiovascular Medicine & Radiology Stanford University School of Medicine Lorry I. Lokey Stem Cell Research Building 265 Campus Drive, Rm G1120B Stanford, CA 94305-5454 Phone: (650) 736-2246 (1)
IGF, University of Montpellier, CNRS, INSERM, Montpellier, France (1)
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China (1)
Marseille Protéomique, CRCM, Inserm, CNRS, Institut Paoli Calmettes, Aix-Marseille Université (1)

IsPrivate

False (14)

Classification

protozoa (2)
bacteria (1)

Modification

4x(2)H labeled dimethylated L-lysine (1)

Study type

Transcription profiling by array (1218)
RNA-seq of coding RNA (84)
Unknown experiment type (70)
Comparative genomic hybridization by array (42)
Other (41)
ChIP-chip by tiling array (33)
Methylation profiling by array (23)
Transcription profiling by tiling array (21)
ChIP-seq (20)
ChIP-chip by array (8)
RNA-seq of non coding RNA (8)
MicroRNA profiling by array (6)
DNA-seq (6)
RNAi profiling by array (5)
Genotyping by array (5)
RNA-seq of coding RNA from single cells (5)
Single nucleus RNA sequencing (4)
Proteomic profiling by array (4)
Methylation profiling by high throughput sequencing (4)
Human - Two-color microarray (3)
Cell line - High-throughput sequencing (3)
Transcription profiling by SAGE (2)
Human - One-color microarray (2)
Animal - High-throughput sequencing (2)
Differential (1)
Cell line - Two-color microarray (1)
Plant - Two-color microarray (1)
One-color microarray (1)
High-throughput sequencing (1)
Antigen profiling (1)

Release Date

2010 (425)
2022 (406)
2021 (396)
2023 (377)
2012 (355)
2013 (349)
2025 (347)
2020 (346)
2015 (327)
2014 (311)
2019 (305)
2016 (300)
2011 (300)
2024 (292)
2018 (277)
2017 (249)
2008 (219)
2009 (163)
2007 (78)
2026 (49)
2006 (49)
2005 (43)
2004 (24)
2003 (10)
2001 (6)
2002 (4)
1999 (2)
2000 (1)
1997 (1)
1996 (1)

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In vivo Brain GPCR Signaling Elucidated by Phosphoproteomics

Obtaining a systems view of G protein-coupled receptor (GPCR) signaling in its native environment is the key in development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR) as model GPCR, we employed high-throughput phosphoproteomics to investigate downstream signa...

ORGANISM(S): Mus musculus (Mouse)

2018-06-15 | PXD006637 | Pride

Gpcr brain phosphoproteomics

Bush2016 - Simplified Carrousel model of GPCR

Bush2016 - Simplified Carrousel model of GPCR This model is described in the article: Yeast GPCR signaling reflects the fraction of occupied receptors, not the number. Bush A, Vasen G, Constantinou A, Dunayevich P, Patop IL, Blaustein M, Colman-Lerner A. Mol. Syst. Biol. 2...

2024-09-02 | BIOMD0000000637 | BioModels

Ice breaking in GPCR structural biology.

Not available

S-EPMC4077136 | biostudies-literature

Bush2016 - Extended Carrousel model of GPCR-RGS

Bush2016 - Extended Carrousel model of GPCR-RGS This model is described in the article: Yeast GPCR signaling reflects the fraction of occupied receptors, not the number. Bush A, Vasen G, Constantinou A, Dunayevich P, Patop IL, Blaustein M, Colman-Lerner A. Mol. Syst. Biol....

2024-09-02 | BIOMD0000000638 | BioModels

Croft2013 - GPCR-RGS interaction that compartmentalizes RGS activity

Croft2013 - GPCR-RGS interaction that compartmentalizes RGS activity Through modelling studies, the classic quaternary complex (ligand-GPCR-G-RGS) has been extended to include an additional layer of regulation through GPCR-RGS interactions, which facilitate the compartmentalization...

2024-09-02 | BIOMD0000000479 | BioModels

Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges.

Not available

S-EPMC4126895 | biostudies-literature

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment.

Not available

S-EPMC3154726 | biostudies-literature

Exploring GPCR-arrestin interfaces with genetically encoded crosslinkers

-arrestins (arr1 and arr2) are ubiquitous regulators of G protein-coupled receptor (GPCR) signalling. Available data suggest that -arrestins dock to different receptors in different ways. However, the structural characterization of arrestin-GPCR complexes is challenging and alternative approaches to...

ORGANISM(S): Homo sapiens (Human)

2020-09-21 | PXD020418 | Pride

-arrestins / genetically encoded crosslinkers / g protein-coupled receptor / gpcr-arrestin complexes / live cells

Community-wide assessment of GPCR structure modelling and ligand docking: GPCR Dock 2008.

Not available

S-EPMC2728591 | biostudies-literature

Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis

This SuperSeries is composed of the following subset Series: GSE25886: Analysis of mRNA levels of GPCR and GPCR-related signaling proteins in 3 mouse cell lines: AtT20, BV2 and N18 GSE25894: Analysis of mRNA levels of GPCR and GPCR-related signaling proteins in the HEK293 cell line Refer to individu...

ORGANISM(S): Homo sapiens

2011-02-01 | E-GEOD-25901 | biostudies-arrayexpress

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6723 Results

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