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MetabolomicsSevere hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice
Abstract Aim: Circulating triglyceride and triglyceride-rich lipoprotein (TRL) accumulation is increasingly recognized as a residual atherosclerotic risk, but their specific effect in cardiac remodeling and heart failure (HF) remain largely unexplored. Here we investigated this issue in Gpihbp1 knoc...
2026-06-11 | MTBLS14749 | MetaboLights
GenomicsSevere hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice
Severe hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice
PRJNA1477037 | ENA
TranscriptomicsSevere hyperchylomicronemia sensitizes the heart to pathological remodeling: evidence from GPIHBP1 deficient mice
This dataset contains bulk RNA sequencing data generated from cardiac tissues of wild-type (WT) and Gpihbp1 knockout (Gpihbp1−/−) mice. GPIHBP1 deficiency disrupts intravascular triglyceride-rich lipoprotein hydrolysis and results in severe hyperchylomicronemia. To investigate the molecular changes ...
ORGANISM(S): Mus musculus 
2026-06-15 | GSE334977 | GEO
UnknownGPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding.
Not available
S-EPMC4329087 | biostudies-literature
UnknownMutating a conserved cysteine in GPIHBP1 reduces amounts of GPIHBP1 in capillaries and abolishes LPL binding.
Not available
S-EPMC5496041 | biostudies-literature
UnknownDeletion of GPIHBP1 causing severe chylomicronemia.
Not available
S-EPMC3319888 | biostudies-literature
UnknownAutoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia.
Not available
S-EPMC5555413 | biostudies-literature
UnknownFunctional validation of GPIHBP1 and identification of a functional mutation in GPIHBP1 for milk fat traits in dairy cattle.
Not available
S-EPMC5561204 | biostudies-literature
UnknownGPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.
Not available
S-EPMC6594755 | biostudies-literature
UnknownChylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase.
Not available
S-EPMC2811263 | biostudies-literature
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