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GenomicsTranscriptomic profiling of A549 cells in response to Dexamethasone, in the context of GR inhibition based on antagonists as well as a novel GR-PROTAC
Transcriptomic profiling of A549 cells in response to Dexamethasone, in the context of GR inhibition based on antagonists as well as a novel GR-PROTAC
PRJNA952714 | ENA
ProteomicsHarnessing PROTAC technology to combat stress hormone receptor activation
We want to quantify the proteome alteration following PROTAC mediated Glucocorticoid receptor depletion in vitro.
ORGANISM(S): Homo sapiens (Human) 
2023-12-11 | PXD046949 | Pride
Gr protac A549 Lc-ms/ms 
TranscriptomicsTranscriptomic profiling of A549 cells in response to Dexamethasone, in the context of GR inhibition based on antagonists as well as a novel GR-PROTAC
Glucocorticoid receptors (GR) are important therapeutic targets due to regulation of stress hormones, glucocorticoids (GCs). GCs are altered in neuropsychiatric diseases, but also in cancers and autoimmunes. GR antagonists show some success in modulating GC levels. Yet, occupancy-driven mode of acti...
ORGANISM(S): Homo sapiens 
2023-11-12 | GSE229084 | GEO
UnknownHarnessing PROTAC technology to combat stress hormone receptor activation.
Not available
S-EPMC10710461 | biostudies-literature
UnknownSerum- and glucocorticoid-induced kinase 3 orchestrates glucocorticoid signaling to facilitate chromatin remodeling during murine adipogenesis.
Not available
S-EPMC12483569 | biostudies-literature
UnknownThe ETO2 transcriptional cofactor maintains acute leukemia by driving a MYB/EP300-dependent stemness program.
Not available
S-EPMC11187848 | biostudies-literature
UnknownWEE1 inhibitors synergise with mRNA translation defects via activation of the kinase GCN2.
Not available
S-EPMC12511557 | biostudies-literature
GenomicsSGK3 Orchestrates Glucocorticoid Signaling to Facilitate Chromatin Remodeling During Adipogenesis
SGK3 Orchestrates Glucocorticoid Signaling to Facilitate Chromatin Remodeling During Adipogenesis
PRJNA1116801 | ENA
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