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TranscriptomicsThe N-glycosylated isoform of M-NM-2-integrin as a potential biomarker and target in HER-2+ BC refractory to HER-2 targeted therapies.
Acquired resistance to trastuzumab, a rationally designed HER-2 targeting antibody, remains a major hurdle in management of HER-2 positive breast cancer (HER-2+ BC) patients. Potential resistance mechanisms are numerous, derived primarily from studies where HER-2 positive cell lines are chronically...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-40152 | biostudies-arrayexpress
TranscriptomicsPancreatic islet expression profiling in diabetes prone C57BLKS/J mice vs C57BL6/J mice.
C57BLKS/J mice are susceptible to diabetes, because of islet dysfunction, whereas C57BL6/J mice are not. Differences in gene expression between the two strains may account for this sensitivity. Furthermore these differences may only be evident in the hyperstimulated (diabetic or hyperglycemic) state...
ORGANISM(S): Mus musculus 
2008-12-30 | E-GEOD-11257 | biostudies-arrayexpress
MetabolomicsTranscript, protein and metabolite temporal dynamics in the CAM plant Agave
Already a proven mechanism for drought sustainability, crassulacean acid metabolism (CAM) is a specialized type of photosynthesis that maximizes water-use efficiency (WUE) via an inverse (compared to C3 and C4 photosynthesis-performing species) day/night pattern of stomatal closure/opening to shift ...
2017-10-13 | MTBLS363 | MetaboLights
TranscriptomicsRNA-seq transcriptome profiling of the psychrophilic diatom Fragilariopsis cylindrus grown at 0 degree Celsius and two levels of salinity
The data set described here complements data available under accession number E-MTAB-5153. We performed bulk RNA-sequencing experiments to examine gene expression in the genome of the cold-adapted (psychrophilic) marine diatom Fragilariopsis cylindrus growing at 0 degree Celsius and salinity of 34 ...
ORGANISM(S): Fragilariopsis cylindrus 
2022-04-30 | E-MTAB-8665 | biostudies-arrayexpress
UnknownRandomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: long-term report of efficacy and toxicity.
Not available
S-EPMC4239304 | biostudies-literature
UnknownPhase I/II Trial of Labetuzumab Govitecan (Anti-CEACAM5/SN-38 Antibody-Drug Conjugate) in Patients With Refractory or Relapsing Metastatic Colorectal Cancer.
Not available
S-EPMC8259133 | biostudies-literature
UnknownEfficacy and Safety of Anti-Trop-2 Antibody Drug Conjugate Sacituzumab Govitecan (IMMU-132) in Heavily Pretreated Patients With Metastatic Triple-Negative Breast Cancer.
Not available
S-EPMC5559902 | biostudies-literature
UnknownFlavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis.
Not available
S-EPMC4274068 | biostudies-literature
UnknownGenomic surveillance of multidrug-resistant Klebsiella in Wales reveals persistent spread of Klebsiella pneumoniae ST307 and adaptive evolution of pOXA-48-like plasmids.
Not available
S-EPMC10272877 | biostudies-literature
TranscriptomicsCpG islands Methylation Profiling by DMH in Epithelial Ovarian Cancer: Screening Set
We have systematically profiled DNA methylation at promoter CpG islands (CGIs) in ovarian cancer. Epithelial ovarian tumours, excluding mucinous and clear cell cancers, prospectively collected through a cohort study, were analyzed by differential methylation hybridization (DMH) (Nouzova M et al, 200...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-23240 | biostudies-arrayexpress
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